PDB entry 2jcc

View 2jcc on RCSB PDB site
Description: ah3 recognition of mutant hla-a2 w167a
Class: immune system
Keywords: glycoprotein, immune system, transmembrane, immunoglobulin domain, host-virus interaction, MHC I, membrane, receptor, polymorphism, pyrrolidone carboxylic acid, imunoregulatory complex, class I MHC-tcr co-crystal, ubl conjugation, immune response, hypothetical protein
Deposited on 2006-12-21, released 2007-10-09
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.244
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01892 (0-274)
      • engineered mutation (166)
    Domains in SCOPe 2.03: d2jcca1, d2jcca2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2JCC (1-End)
    • Uniprot P61769 (1-99)
    Domains in SCOPe 2.03: d2jccb_
  • Chain 'C':
    Compound: p1049
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'E':
    Compound: tcr alpha
    Species: MUS MUSCULUS [TaxId:10090]
    Domains in SCOPe 2.03: d2jcce1, d2jcce2
  • Chain 'F':
    Compound: tcr beta
    Species: MUS MUSCULUS [TaxId:10090]
    Domains in SCOPe 2.03: d2jccf1, d2jccf2
  • Chain 'H':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01892 (0-274)
      • engineered mutation (166)
    Domains in SCOPe 2.03: d2jcch1, d2jcch2
  • Chain 'I':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2JCC (1-End)
    • Uniprot P61769 (1-99)
    Domains in SCOPe 2.03: d2jcci_
  • Chain 'J':
    Compound: p1049
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'L':
    Compound: tcr alpha
    Species: MUS MUSCULUS [TaxId:10090]
    Domains in SCOPe 2.03: d2jccl1, d2jccl2
  • Chain 'M':
    Compound: tcr beta
    Species: MUS MUSCULUS [TaxId:10090]
    Domains in SCOPe 2.03: d2jccm1, d2jccm2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2jccA (A:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvealrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2jccB (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2jccE (E:)
    mdsvtqteglvtlteglpvmlnctyqstyspflfwyvqhlneapklllksftdnkrpehq
    gfhatlhkssssfhlqkssaqlsdsalyycalflasssfsklvfgqgtslsvvpniqnpe
    pavyqlkdprsqdstlclftdfdsqinvpktmesgtfitdktvldmkamdsksngaiaws
    nqtsftcqdifket
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >2jccF (F:)
    meaavtqsprskvavtggkvtlschqtnnhdymywyrqdtghglrlihysyvadstekgd
    ipdgykasrpsqenfslilelaslsqtavyfcassdwvsyeqyfgpgtrltvledlrnvt
    ppkvslfepskaeiankqkatlvclargffpdhvelswwvngkevhsgvstdpqaykesn
    ysyalssrlrvsatfwhnprnhfrcqvqfhglseedkwpegspkpvtqnisaeawgra
    

    Sequence, based on observed residues (ATOM records): (download)
    >2jccF (F:)
    eaavtqsprskvavtggkvtlschqtnnhdymywyrqdtghglrlihysyvadstekgdi
    pdgykasrpsqenfslilelaslsqtavyfcassdwvsyeqyfgpgtrltvledlrnvtp
    pkvslfepskaeiankqkatlvclargffpdhvelswwvngkevhsgvstdpqaykesny
    syalssrlrvsatfwhnprnhfrcqvqfhglseedkwpegspkpvtqnisaeawgra
    

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2jccH (H:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvealrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2jccI (I:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'J':
    No sequence available.

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2jccL (L:)
    mdsvtqteglvtlteglpvmlnctyqstyspflfwyvqhlneapklllksftdnkrpehq
    gfhatlhkssssfhlqkssaqlsdsalyycalflasssfsklvfgqgtslsvvpniqnpe
    pavyqlkdprsqdstlclftdfdsqinvpktmesgtfitdktvldmkamdsksngaiaws
    nqtsftcqdifket
    

  • Chain 'M':
    Sequence, based on SEQRES records: (download)
    >2jccM (M:)
    meaavtqsprskvavtggkvtlschqtnnhdymywyrqdtghglrlihysyvadstekgd
    ipdgykasrpsqenfslilelaslsqtavyfcassdwvsyeqyfgpgtrltvledlrnvt
    ppkvslfepskaeiankqkatlvclargffpdhvelswwvngkevhsgvstdpqaykesn
    ysyalssrlrvsatfwhnprnhfrcqvqfhglseedkwpegspkpvtqnisaeawgra
    

    Sequence, based on observed residues (ATOM records): (download)
    >2jccM (M:)
    eaavtqsprskvavtggkvtlschqtnnhdymywyrqdtghglrlihysyvadstekgdi
    pdgykasrpsqenfslilelaslsqtavyfcassdwvsyeqyfgpgtrltvledlrnvtp
    pkvslfepskaeiankqkatlvclargffpdhvelswwvngkevhsgvstdpqaykesny
    syalssrlrvsatfwhnprnhfrcqvqfhglseedkwpegspkpvtqnisaeawgra