PDB entry 2ja0

View 2ja0 on RCSB PDB site
Description: crystal structure of human ste20-like kinase bound to 4-(4-(5-cyclopropyl-1h-pyrazol-3-ylamino)-quinazolin-2-ylamino)-benzonitrile
Class: transferase
Keywords: serine/threonine-protein kinase, ATP-binding, phosphorylation, muscle development, kinase, apoptosis, transferase, coiled coil, germinal centre kinase, serine-threonine kinase 2, nucleotide-binding, alternative splicing, serine-threonine-protein kinase
Deposited on 2006-11-16, released 2007-01-16
The last revision prior to the SCOPe 2.06 freeze date was dated 2007-03-20, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.2
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ste20-like serine/threonine-protein kinase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • PDB 2JA0
      • engineered mutation (29)
      • microheterogeneity (187)
    • Uniprot Q9H2G2
    Domains in SCOPe 2.06: d2ja0a_
  • Heterogens: SCN, EDO, HQP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ja0A (A:)
mhhhhhhssgvdlgtenlyfqsmkqyehvtrdlnpedfweiigelgdgafgkvykaqnke
tsvlaaakvidtkseeeledymveidilascdhpnivklldafyyennlwiliefcagga
vdavmlelerpltesqiqvvckqtldalnylhdnkiihrdlkagnilftldgdikladfg
vsakntrtiqrrdsfigtpywmapevvmcetskdrpydykadvwslgitliemaeiepph
helnpmrvllkiaksepptlaqpsrwssnfkdflkkcleknvdarwttsqllqhpfvtvd
snkpireliaeakaevteevedgke

    Sequence, based on observed residues (ATOM records): (download) 
    >2ja0A (A:)
yehvtrdlnpedfweiigelgdfgkvykaqnketsvlaaakvidtkseeeledymveidi
lascdhpnivklldafyyennlwiliefcaggavdavmlelerpltesqiqvvckqtlda
lnylhdnkiihrdlkagnilftldgdikladfgvsakntrtiqrrdsfigtpywmapevv
mcetskdrpydykadvwslgitliemaeiepphhelnpmrvllkiaksepptlaqpsrws
snfkdflkkcleknvdarwttsqllqhpfvtvdsnkpireliaeak