PDB entry 2j4e

View 2j4e on RCSB PDB site
Description: the itp complex of human inosine triphosphatase
Class: hydrolase
Keywords: nucleotide metabolism, itp, imp, hydrolase, disease mutation, inosine triphosphate pyrophosphohydrolase, inosine triphosphatase deficiency
Deposited on 2006-08-29, released 2006-09-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-11-20, with a file datestamp of 2013-11-15.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.204
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: inosine triphosphate pyrophosphatase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2j4ea_
  • Chain 'B':
    Compound: inosine triphosphate pyrophosphatase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2J4E (Start-1)
    • Uniprot Q9BY32 (2-End)
    Domains in SCOPe 2.07: d2j4eb_
  • Chain 'C':
    Compound: inosine triphosphate pyrophosphatase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2J4E (Start-1)
    • Uniprot Q9BY32 (2-End)
    Domains in SCOPe 2.07: d2j4ec_
  • Chain 'D':
    Compound: inosine triphosphate pyrophosphatase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2J4E (Start-1)
    • Uniprot Q9BY32 (2-195)
    Domains in SCOPe 2.07: d2j4ed_
  • Chain 'E':
    Compound: inosine triphosphate pyrophosphatase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2J4E (Start-1)
    • Uniprot Q9BY32 (2-End)
    Domains in SCOPe 2.07: d2j4ee_
  • Chain 'F':
    Compound: inosine triphosphate pyrophosphatase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2J4E (Start-1)
    • Uniprot Q9BY32 (2-End)
    Domains in SCOPe 2.07: d2j4ef_
  • Chain 'G':
    Compound: inosine triphosphate pyrophosphatase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2J4E (Start-1)
    • Uniprot Q9BY32 (2-End)
    Domains in SCOPe 2.07: d2j4eg_
  • Chain 'H':
    Compound: inosine triphosphate pyrophosphatase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2j4eh_
  • Heterogens: ITT, MG, POP, IMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2j4eA (A:)
    gsmaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcq
    eavrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctf
    alstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshr
    frallelqeyfgslaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2j4eA (A:)
    aaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcqeav
    rqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctfals
    tpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshrfrallelq
    eyfg
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2j4eB (B:)
    gsmaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcq
    eavrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctf
    alstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshr
    frallelqeyfgslaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2j4eB (B:)
    smaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcqe
    avrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctfa
    lstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshrf
    rallelqeyfgsla
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2j4eC (C:)
    gsmaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcq
    eavrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctf
    alstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshr
    frallelqeyfgslaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2j4eC (C:)
    smaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcqe
    avrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctfa
    lstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshrf
    rallelqeyfgsla
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >2j4eD (D:)
    gsmaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcq
    eavrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctf
    alstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshr
    frallelqeyfgslaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2j4eD (D:)
    smaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcqe
    avrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctfa
    lstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshrf
    rallelqeyfgslaa
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >2j4eE (E:)
    gsmaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcq
    eavrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctf
    alstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshr
    frallelqeyfgslaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2j4eE (E:)
    smaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcqe
    avrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctfa
    lstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshrf
    rallelqeyf
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >2j4eF (F:)
    gsmaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcq
    eavrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctf
    alstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshr
    frallelqeyfgslaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2j4eF (F:)
    smaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcqe
    avrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctfa
    lstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshrf
    rallelqeyfgsla
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >2j4eG (G:)
    gsmaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcq
    eavrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctf
    alstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshr
    frallelqeyfgslaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2j4eG (G:)
    smaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcqe
    avrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctfa
    lstpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshrfralle
    lqeyfg
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >2j4eH (H:)
    gsmaaslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcq
    eavrqvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctf
    alstgdpsqpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshr
    frallelqeyfgslaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >2j4eH (H:)
    aslvgkkivfvtgnakkleevvqilgdkfpctlvaqkidlpeyqgepdeisiqkcqeavr
    qvqgpvlvedtclcfnalgglpgpyikwfleklkpeglhqllagfedksayalctfalst
    qpvrlfrgrtsgrivaprgcqdfgwdpcfqpdgyeqtyaempkaeknavshrfrallelq
    eyfg