PDB entry 2j2i

View 2j2i on RCSB PDB site
Description: crystal structure of the humab pim1 in complex with ly333531
Class: transferase
Keywords: transferase, nucleotide-binding, alternative initiation, serine/threonine-protein kinase, ATP-binding, metal-binding, proto-oncogene, kinase, cancer, leukemia, manganese, nuclear protein, proto- oncogene, phosphorylation
Deposited on 2006-08-16, released 2007-02-13
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.18
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: Proto-oncogene serine/threonine-protein kinase Pim-1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11309
      • engineered mutation (249)
    Domains in SCOPe 2.03: d2j2ib_
  • Heterogens: SO4, LY4, HOH

PDB Chain Sequences:

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2j2iB (B:)
mllskinslahlraapcndlhatklapgkekeplesqyqvgpllgsggfgsvysgirvsd
nlpvaikhvekdrisdwgelpngtrvpmevvllkkvssgfsgvirlldwferpdsfvlil
erpepvqdlfdfitergalqeelarsffwqvleavrhchncgvlhrdikdenilidlnrg
elklidfgsgallkdtvytdfdgtrvysppewiryhryhgrsaavwslgillydmvcgdi
pfehdeeiiggqvffrqrvssecqhlirwclalrpsdrptfeeiqnhpwmqdvllpqeta
eihlhslspgps

    Sequence, based on observed residues (ATOM records): (download) 
    >2j2iB (B:)
plesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvl
lkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvl
eavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppew
iryhryhgrsaavwslgillydmvcgdipfehdeeiiggqvffrqrvssecqhlirwcla
lrpsdrptfeeiqnhpwmqdvllpqetaeihlh