PDB entry 2j21

View 2j21 on RCSB PDB site
Description: human p53 core domain mutant m133l-v203a-n239y-n268d-r282w
Class: nuclear protein
Keywords: second-site suppressor mutation, disease mutation, nuclear protein, phosphorylation, tumor suppressor, alternative splicing, li-fraumeni syndrome, li- fraumeni syndrome, host-virus interaction, transcription, metal-binding, anti-oncogene, DNA-binding, transferase, polymorphism, glycoprotein, zinc, activator, apoptosis, cell cycle, acetylation, p53 DNA-binding domain, transcription regulation, superstable mutant, DNA-binding protein
Deposited on 2006-08-15, released 2006-09-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.198
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (39)
      • engineered mutation (109)
      • engineered mutation (145)
      • engineered mutation (174)
      • engineered mutation (188)
    Domains in SCOPe 2.07: d2j21a_
  • Chain 'B':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (39)
      • engineered mutation (109)
      • engineered mutation (145)
      • engineered mutation (174)
      • engineered mutation (188)
    Domains in SCOPe 2.07: d2j21b_
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2j21A (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpyeppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdwrteeenlrkkgephhelppgstkralpnnt

    Sequence, based on observed residues (ATOM records): (download) 
    >2j21A (A:)
svpsqktyqgsygfrlgflhsvtctyspalnklfcqlaktcpvqlwvdstpppgtrvram
aiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfrhsvvvpy
eppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevrvcacpgr
dwrteeen

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2j21B (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnklfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfr
hsvvvpyeppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevr
vcacpgrdwrteeenlrkkgephhelppgstkralpnnt

    Sequence, based on observed residues (ATOM records): (download) 
    >2j21B (B:)
svpsqktyqgsygfrlgflhvtctyspalnklfcqlaktcpvqlwvdstpppgtrvrama
iykqsqhmtevvrrcphhercsdsdglappqhlirvegnlraeylddrntfrhsvvvpye
ppevgsdcttihynymcysscmggmnrrpiltiitledssgnllgrdsfevrvcacpgrd
wrteeenl