PDB entry 2j0d

View 2j0d on RCSB PDB site
Description: Crystal structure of human P450 3A4 in complex with erythromycin
Class: oxidoreductase
Keywords: polymorphism, erythromycin, monooxygenase, metal-binding, transmembrane, oxidoreductase, endoplasmic reticulum, drug metabolizing enzyme, p450, nadp, iron, heme, cyp3a4, membrane, microsome
Deposited on 2006-08-02, released 2006-09-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cytochrome p450 3a4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2J0D
      • conflict (369)
    • Uniprot P08684
    Domains in SCOPe 2.08: d2j0da1
  • Chain 'B':
    Compound: cytochrome p450 3a4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2J0D
      • conflict (369)
    • Uniprot P08684
    Domains in SCOPe 2.08: d2j0db1
  • Heterogens: HEM, ERY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2j0dA (A:)
maygthshglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvl
aitdpdmiktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgkl
kemvpiiaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdp
fventkkllrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrle
dtqkhrvdflqlmidsqnsketeshkalsdlelvaqsiififagyettssvlsfimyela
thpdvqqklqeeidavlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkdve
ingmfipkgvvvmipsyalhrdpkywtepekflperfskknkdnidpyiytpfgsgprnc
igmrfalmnmklalirvlqnfsfkpcketqiplklslggllqpekpvvlkvesrdgtvsg
ahhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2j0dA (A:)
shglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvlaitdpd
miktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgklkemvpi
iaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidsnpqdpfventkkl
lrffflsitvfpflipilevlnicvfprevtnflrksvkrmkesrflqlmidsqnshkal
sdlelvaqsiififagyettssvlsfimyelathpdvqqklqeeidavlpnkapptydtv
lqmeyldmvvnetlrlfpiamrlervckkdveingmfipkgvvvmipsyalhrdpkywte
pekflperfskknkdnidpyiytpfgsgprncigmrfalmnmklalirvlqnfsfkpcke
tqiplklslggllqpekpvvlkvesr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2j0dB (B:)
maygthshglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvl
aitdpdmiktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgkl
kemvpiiaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdp
fventkkllrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrle
dtqkhrvdflqlmidsqnsketeshkalsdlelvaqsiififagyettssvlsfimyela
thpdvqqklqeeidavlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkdve
ingmfipkgvvvmipsyalhrdpkywtepekflperfskknkdnidpyiytpfgsgprnc
igmrfalmnmklalirvlqnfsfkpcketqiplklslggllqpekpvvlkvesrdgtvsg
ahhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2j0dB (B:)
gthshglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvlait
dpdmiktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgklkem
vpiiaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidsnpqdpfvent
kklpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrflqlmidsqhkals
dlelvaqsiififagyettssvlsfimyelathpdvqqklqeeidavlpnkapptydtvl
qmeyldmvvnetlrlfpiamrlervckkdveingmfipkgvvvmipsyalhrdpkywtep
ekflperfskknkdnidpyiytpfgsgprncigmrfalmnmklalirvlqnfsfkpcket
qiplklslggllqpekpvvlkvesr