PDB entry 2izz

View 2izz on RCSB PDB site
Description: Crystal structure of human pyrroline-5-carboxylate reductase
Class: oxidoreductase
Keywords: amino-acid biosynthesis, nadp, oxidoreductase, proline biosynthesis
Deposited on 2006-07-31, released 2006-08-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyrroline-5-carboxylate reductase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2IZZ (Start-21)
    • Uniprot P32322 (22-End)
    Domains in SCOPe 2.08: d2izza1, d2izza2, d2izza3
  • Chain 'B':
    Compound: Pyrroline-5-carboxylate reductase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2IZZ (Start-21)
    • Uniprot P32322 (22-End)
    Domains in SCOPe 2.08: d2izzb1, d2izzb2, d2izzb3
  • Chain 'C':
    Compound: Pyrroline-5-carboxylate reductase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2IZZ (Start-21)
    • Uniprot P32322 (22-End)
    Domains in SCOPe 2.08: d2izzc1, d2izzc2, d2izzc3
  • Chain 'D':
    Compound: Pyrroline-5-carboxylate reductase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2IZZ (Start-21)
    • Uniprot P32322 (22-End)
    Domains in SCOPe 2.08: d2izzd1, d2izzd2, d2izzd3
  • Chain 'E':
    Compound: Pyrroline-5-carboxylate reductase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2IZZ
    • Uniprot P32322 (22-End)
    Domains in SCOPe 2.08: d2izze1, d2izze2
  • Heterogens: NAD, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2izzA (A:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >2izzA (A:)
smsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnket
vqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvir
cmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpa
yaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggati
halhvlesggfrsllinaveascirtrelqsm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2izzB (B:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >2izzB (B:)
nlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltp
hnketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpa
prvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtgls
gsgpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvssp
ggatihalhvlesggfrsllinaveascirtrelqsmad

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2izzC (C:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >2izzC (C:)
smsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnket
vqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvir
cmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpa
yaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggati
halhvlesggfrsllinaveascirtrelqsmadqe

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2izzD (D:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >2izzD (D:)
lyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltph
nketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpap
rvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsg
sgpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspg
gatihalhvlesggfrsllinaveascirtrelqsm

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2izzE (E:)
mhhhhhhssgvdlgtenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmd
latvsalrkmgvkltphnketvqhsdvlflavkphiipfildeigadiedrhivvscaag
vtissiekklsafrpaprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgf
cteveedlidavtglsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmll
hseqhpgqlkdnvsspggatihalhvlesggfrsllinaveascirtrelqsmadqeqvs
paaikktildkvkldspagtal

    Sequence, based on observed residues (ATOM records): (download) 
    >2izzE (E:)
msvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnketv
qhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvirc
mtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpay
aftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggatih
alhvlesggfrsllinaveascirtrelqsma