PDB entry 2iwi

View 2iwi on RCSB PDB site
Description: crystal structure of the human pim2 in complex with a ruthenium organometallic ligand ru1
Class: transferase
Keywords: nucleotide-binding, serine/threonine-protein kinase, pim2, kinase, cancer, leukemia, transferase, ATP-binding, proto-oncogene, phosphorylation
Deposited on 2006-06-30, released 2006-08-02
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-11-03, with a file datestamp of 2009-10-30.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.244
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase pim-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2iwia_
  • Chain 'B':
    Compound: serine/threonine-protein kinase pim-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2iwib_
  • Heterogens: HB1

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2iwiA (A:)
smltkplqgppappgtptpppggkdreafeaeyrlgpllgkggfgtvfaghrltdrlqva
ikviprnrvlgwsplsdsvtcplevallwkvgaggghpgvirlldwfetqegfmlvlerp
lpaqdlfdyitekgplgegpsrcffgqvvaaiqhchsrgvvhrdikdenilidlrrgcak
lidfgsgallhdepytdfdgtrvysppewisrhqyhalpatvwslgillydmvcgdipfe
rdqeileaelhfpahvspdccalirrclapkpssrpsleeilldpwmqtpaedvplnpsk
ggpaplawsllp

    Sequence, based on observed residues (ATOM records): (download) 
    >2iwiA (A:)
yrlgpllgkggfgtvfaghrltdrlqvaikviprnrvlvtcplevallwkvgaggghpgv
irlldwffmlvlerplpaqdlfdyitekgplgegpsrcffgqvvaaiqhchsrgvvhrdi
kdenilidlrrgcaklidfgsgallhdepytdfdgtrvysppewisrhqyhalpatvwsl
gillydmvcgdipferdqeileaelhfpahvspdccalirrclapkpssrpsleeilldp
wmqt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2iwiB (B:)
smltkplqgppappgtptpppggkdreafeaeyrlgpllgkggfgtvfaghrltdrlqva
ikviprnrvlgwsplsdsvtcplevallwkvgaggghpgvirlldwfetqegfmlvlerp
lpaqdlfdyitekgplgegpsrcffgqvvaaiqhchsrgvvhrdikdenilidlrrgcak
lidfgsgallhdepytdfdgtrvysppewisrhqyhalpatvwslgillydmvcgdipfe
rdqeileaelhfpahvspdccalirrclapkpssrpsleeilldpwmqtpaedvplnpsk
ggpaplawsllp

    Sequence, based on observed residues (ATOM records): (download) 
    >2iwiB (B:)
gkdreafeaeyrlgpllgkggfgtvfaghrltdrlqvaikviprtcplevallwkvgagg
ghpgvirlldwfefmlvlerplpaqdlfdyitekgplgegpsrcffgqvvaaiqhchsrg
vvhrdikdenilidlrrgcaklidfgsgallhdepytdfdgtrvysppewisrhqyhalp
atvwslgillydmvcgdipferdqeileaelhfpahvspdccalirrclapkpssrpsle
eilldpwmq