PDB entry 2iw9

View 2iw9 on RCSB PDB site
Description: structure of human thr160-phospho cdk2-cyclin a complexed with a bisanilinopyrimidine inhibitor
Class: cell cycle
Keywords: phosphorylation, nucleotide-binding, serine/threonine-protein kinase, cell cycle complex, kinase, mitosis, cell cycle, transferase
Deposited on 2006-06-27, released 2006-09-06
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.212
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cell division protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (4-End)
      • expression tag (3)
      • engineered mutation (92)
    Domains in SCOPe 2.03: d2iw9a_
  • Chain 'B':
    Compound: Cyclin-A2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2iw9b1, d2iw9b2
  • Chain 'C':
    Compound: Cell division protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (4-End)
      • expression tag (3)
      • engineered mutation (92)
    Domains in SCOPe 2.03: d2iw9c_
  • Chain 'D':
    Compound: Cyclin-A2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2iw9d1, d2iw9d2
  • Heterogens: 4SP, SGM, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2iw9A (A:)
gpgsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllk
elnhpnivklldvihtenklylvfeflhqdlktfmdasaltgiplpliksylfqllqgla
fchshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillg
ckyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdy
kpsfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl
rl

    Sequence, based on observed residues (ATOM records): (download) 
    >2iw9A (A:)
smenfqkvekigegtygvvykarnkltgevvalkkirlegvpstaireisllkelnhpni
vklldvihtenklylvfeflhqdlktfmdasaltgiplpliksylfqllqglafchshrv
lhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyysta
vdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkw
arqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2iw9B (B:)
mevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetl
hlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvl
rmehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylp
sviagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirek
yknskyhgvsllnppetlnl

    Sequence, based on observed residues (ATOM records): (download) 
    >2iw9B (B:)
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyittytkkqvlrmehl
vlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsviag
aafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyknsk
yhgvsllnppetlnl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2iw9C (C:)
gpgsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllk
elnhpnivklldvihtenklylvfeflhqdlktfmdasaltgiplpliksylfqllqgla
fchshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillg
ckyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdy
kpsfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl
rl

    Sequence, based on observed residues (ATOM records): (download) 
    >2iw9C (C:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlktfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpvvppldedgrsllsqml
hydpnkrisakaalahpffqdvtkpvphl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2iw9D (D:)
mevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetl
hlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvl
rmehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylp
sviagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirek
yknskyhgvsllnppetlnl

    Sequence, based on observed residues (ATOM records): (download) 
    >2iw9D (D:)
yhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhlavn
yidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrmehl
vlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsviag
aafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyknsk
yhgvsllnppetlnl