PDB entry 2ivs

View 2ivs on RCSB PDB site
Description: crystal structure of non-phosphorylated ret tyrosine kinase domain
Class: transferase
Keywords: nucleotide-binding, hirschsprung disease, phosphorylation, disease mutation, phosphotransferase, tyrosine-protein kinase, chromosomal translocation, polymorphism, gdnf receptor, transmembrane, proto-oncogene, tyrosine kinase, ret, kinase, membrane, ATP-binding, transferase
Deposited on 2006-06-16, released 2006-08-14
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.183
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2ivsa_
  • Chain 'B':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2IVS (0-4)
    • Uniprot P07949 (5-End)
    Domains in SCOPe 2.03: d2ivsb_
  • Heterogens: FMT, ACK, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ivsA (A:)
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgpgylgsggsrnsssldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarn
ilvaegrkmkisdfglsrdvyeedsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgv
llweivtlggnpypgipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfa
diskdlekmmvkrr

    Sequence, based on observed residues (ATOM records): (download) 
    >2ivsA (A:)
edpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkmlkenaspselrdl
lsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflresrkvgpgylraltm
gdlisfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfglsrdvyeedsyvkr
sqgripvkwmaieslfdhiyttqsdvwsfgvllweivtlggnpypgipperlfnllktgh
rmerpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmvkr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ivsB (B:)
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgpgylgsggsrnsssldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarn
ilvaegrkmkisdfglsrdvyeedsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgv
llweivtlggnpypgipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfa
diskdlekmmvkrr

    Sequence, based on observed residues (ATOM records): (download) 
    >2ivsB (B:)
gplslsvdafkipkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkmlke
naspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflresrkr
altmgdlisfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfglsrdvgripv
kwmaieslfdhiyttqsdvwsfgvllweivtlggnpypgipperlfnllktghrmerpdn
cseemyrlmlqcwkqepdkrpvfadiskdlekmmvkr