PDB entry 2iu3

View 2iu3 on RCSB PDB site
Description: crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase
Class: hydrolase
Keywords: multifunctional enzyme, transition state analogue, atic, impch, hydrolase, inhibitor, transferase, structure-base, purine biosynthesis
Deposited on 2006-05-27, released 2007-02-20
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.215
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bifunctional purine biosynthesis protein PURH
    Species: Gallus gallus [TaxId:9031]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2iu3a1, d2iu3a2
  • Chain 'B':
    Compound: Bifunctional purine biosynthesis protein PURH
    Species: Gallus gallus [TaxId:9031]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2iu3b1, d2iu3b2
  • Heterogens: K, 203, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2iu3A (A:)
maarqqlallsvsekaglvefarslnalglgliasggtatalrdaglpvrdvsdltgfpe
mlggrvktlhpavhagilarnipednadmnkqdfslvrvvvcnlypfvktvsspgvtvpe
avekidiggvallraaaknharvtvvcdpadyssvakemaaskdkdtsvetrrhlalkaf
thtaqydaaisdyfrkeyskgvsqlplrygmnphqspaqlyttrpklpltvvngspgfin
lcdalnawqlvkelkqalgipaaasfkhvspagaavgiplseeeaqvcmvhdlhktltpl
asayarsrgadrmssfgdfialsdicdvptakiisrevsdgvvapgyeeealkilskkkn
ggycvlqmdpnyepddneirtlyglqlmqkrnnavidrslfknivtknktlpesavrdli
vasiavkytqsnsvcyakdgqvigigagqqsrihctrlagdkanswwlrhhprvlsmkfk
agvkraevsnaidqyvtgtigededlvkwqamfeevpaqlteaekkqwiakltavslssd
affpfrdnvdrakrigvqfivapsgsaadevvieacnelgitlihtnlrlfhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2iu3A (A:)
rqqlallsvsekaglvefarslnalglgliasggtatalrdaglpvrdvsdltgfpemlg
grvktlhpavhagilarnipednadmnkqdfslvrvvvcnlypfvktvsspgvtvpeave
kidiggvallraaaknharvtvvcdpadyssvakemaaskdkdtsvetrrhlalkaftht
aqydaaisdyfrkeyskgvsqlplrygmnphqspaqlyttrpklpltvvngspgfinlcd
alnawqlvkelkqalgipaaasfkhvspagaavgiplseeeaqvcmvhdlhktltplasa
yarsrgadrmssfgdfialsdicdvptakiisrevsdgvvapgyeeealkilskkknggy
cvlqmdpnyepddneirtlyglqlmqkrnnavidrslfknivtknktlpesavrdlivas
iavkytqsnsvcyakdgqvigigagqqsrihctrlagdkanswwlrhhprvlsmkfkagv
kraevsnaidqyvtgtigededlvkwqamfeevpaqlteaekkqwiakltavslssdaff
pfrdnvdrakrigvqfivapsgsaadevvieacnelgitlihtnlrlfhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2iu3B (B:)
maarqqlallsvsekaglvefarslnalglgliasggtatalrdaglpvrdvsdltgfpe
mlggrvktlhpavhagilarnipednadmnkqdfslvrvvvcnlypfvktvsspgvtvpe
avekidiggvallraaaknharvtvvcdpadyssvakemaaskdkdtsvetrrhlalkaf
thtaqydaaisdyfrkeyskgvsqlplrygmnphqspaqlyttrpklpltvvngspgfin
lcdalnawqlvkelkqalgipaaasfkhvspagaavgiplseeeaqvcmvhdlhktltpl
asayarsrgadrmssfgdfialsdicdvptakiisrevsdgvvapgyeeealkilskkkn
ggycvlqmdpnyepddneirtlyglqlmqkrnnavidrslfknivtknktlpesavrdli
vasiavkytqsnsvcyakdgqvigigagqqsrihctrlagdkanswwlrhhprvlsmkfk
agvkraevsnaidqyvtgtigededlvkwqamfeevpaqlteaekkqwiakltavslssd
affpfrdnvdrakrigvqfivapsgsaadevvieacnelgitlihtnlrlfhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2iu3B (B:)
rqqlallsvsekaglvefarslnalglgliasggtatalrdaglpvrdvsdltgfpemlg
grvktlhpavhagilarnipednadmnkqdfslvrvvvcnlypfvktvsspgvtvpeave
kidiggvallraaaknharvtvvcdpadyssvakemaaskdkdtsvetrrhlalkaftht
aqydaaisdyfrkeyskgvsqlplrygmnphqspaqlyttrpklpltvvngspgfinlcd
alnawqlvkelkqalgipaaasfkhvspagaavgiplseeeaqvcmvhdlhktltplasa
yarsrgadrmssfgdfialsdicdvptakiisrevsdgvvapgyeeealkilskkknggy
cvlqmdpnyepddneirtlyglqlmqkrnnavidrslfknivtknktlpesavrdlivas
iavkytqsnsvcyakdgqvigigagqqsrihctrlagdkanswwlrhhprvlsmkfkagv
kraevsnaidqyvtgtigededlvkwqamfeevpaqlteaekkqwiakltavslssdaff
pfrdnvdrakrigvqfivapsgsaadevvieacnelgitlihtnlrlfhh