PDB entry 2itt
View 2itt on RCSB PDB site
Description: crystal structure of egfr kinase domain l858r mutation in complex with aee788
Class: transferase
Keywords: receptor, cell cycle, ATP-binding, transferase, transmembrane, phosphorylation, disease mutation, polymorphism, glycoprotein, anti-oncogene, nucleotide-binding, alternative splicing, aee788, egfr, l858r, kinase, membrane, tyrosine-protein kinase, epidermal growth factor
Deposited on
2006-05-25, released
2007-04-03
The last revision prior to the SCOPe 2.05 freeze date was dated
2009-06-02, with a file datestamp of
2009-05-29.
Experiment type: XRAY
Resolution: 2.73 Å
R-factor: 0.212
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P00533
- engineered mutation (162)
Domains in SCOPe 2.05: d2itta_ - Heterogens: AEE, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2ittA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipqqg
Sequence, based on observed residues (ATOM records): (download)
>2ittA (A:)
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeevpikwmales
ilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvym
imvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlmdeedmddvvdadeyl
ip