PDB entry 2itq
View 2itq on RCSB PDB site
Description: Crystal structure of EGFR kinase domain G719S mutation in complex with AFN941
Class: transferase
Keywords: receptor, cell cycle, ATP-binding, transferase, transmembrane, phosphorylation, disease mutation, glycoprotein, anti-oncogene, nucleotide-binding, afn941, egfr, g719s, staurosporine, membrane, tyrosine-protein kinase, epidermal growth factor
Deposited on
2006-05-25, released
2007-04-03
The last revision prior to the SCOPe 2.03 freeze date was dated
2013-03-27, with a file datestamp of
2013-03-22.
Experiment type: XRAY
Resolution: 2.68 Å
R-factor: 0.2
AEROSPACI score: 0.29
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d2itqa_ - Heterogens: ITQ, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2itqA (A:)
geapnqallrilketefkkikvlssgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipqqg
Sequence, based on observed residues (ATOM records): (download)
>2itqA (A:)
eapnqallrilketefkkikvlssgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdmddvvdadeyli