PDB entry 2isw

View 2isw on RCSB PDB site
Description: Structure of Giardia fructose-1,6-biphosphate aldolase in complex with phosphoglycolohydroxamate
Class: lyase
Keywords: Class II fructose-1,6-bisphosphate aldolase, glycolytic pathway, Giardia lamblia, drug target, X-ray structure, LYASE
Deposited on 2006-10-18, released 2006-12-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.186
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Putative fructose-1,6-bisphosphate aldolase
    Species: Giardia intestinalis [TaxId:5741]
    Gene: ald
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2iswa_
  • Chain 'B':
    Compound: Putative fructose-1,6-bisphosphate aldolase
    Species: Giardia intestinalis [TaxId:5741]
    Gene: ald
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2iswb_
  • Heterogens: ZN, PGH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2iswA (A:)
mplctlrqmlgearkhkygvgafnvnnmeqiqgimkavvqlkspvilqcsrgalkysdmi
ylkklceaalekhpdipicihldhgdtlesvkmaidlgfssvmidashhpfdenvritke
vvayaharsvsveaelgtlggieedvqntvqltepqdakkfveltgvdalavaigtshga
ykfksesdirlaidrvktisdltgiplvmhgsssvpkdvkdminkyggkmpdavgvpies
ivhaigegvckinvdsdsrmamtgairkvfvehpekfdprdylgpgrdaitemlipkika
fgsaghagdykvvsleeakawyk

    Sequence, based on observed residues (ATOM records): (download) 
    >2iswA (A:)
plctlrqmlgearkhkygvgafnvnnmeqiqgimkavvqlkspvilqcsrgalkysdmiy
lkklceaalekhpdipicihldhgdtlesvkmaidlgfssvmidashhpfdenvritkev
vayaharsvsveaelgtlvqltepqdakkfveltgvdalavaigtshgaykfksrlaidr
vktisdltgiplvmhgsssvpkdvkdminkyggkmpdavgvpiesivhaigegvckinvd
sdsrmamtgairkvfvehpekfdprdylgpgrdaitemlipkikafgsaghagdykvvsl
eeakawy

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2iswB (B:)
mplctlrqmlgearkhkygvgafnvnnmeqiqgimkavvqlkspvilqcsrgalkysdmi
ylkklceaalekhpdipicihldhgdtlesvkmaidlgfssvmidashhpfdenvritke
vvayaharsvsveaelgtlggieedvqntvqltepqdakkfveltgvdalavaigtshga
ykfksesdirlaidrvktisdltgiplvmhgsssvpkdvkdminkyggkmpdavgvpies
ivhaigegvckinvdsdsrmamtgairkvfvehpekfdprdylgpgrdaitemlipkika
fgsaghagdykvvsleeakawyk

    Sequence, based on observed residues (ATOM records): (download) 
    >2iswB (B:)
plctlrqmlgearkhkygvgafnvnnmeqiqgimkavvqlkspvilqcsrgalkysdmiy
lkklceaalekhpdipicihldhgdtlesvkmaidlgfssvmidashhpfdenvritkev
vayaharsvsveaelgltepqdakkfveltgvdalavaiglaidrvktisdltgiplvmh
gvpkdvkdminkyggkmpdavpiesivhaigegvckinvdsdsrmamtgairkvfvehpe
kfdprdylgpgrdaitemlipkikafgsaghagdykvvsleeakawyk