PDB entry 2isi

View 2isi on RCSB PDB site
Description: Crystal structure of Ape1 from Homo sapiens in a new crystal form complexed with a ligand
Class: lyase
Keywords: ape1, crystal structure, magnesium
Deposited on 2006-10-17, released 2006-10-31
The last revision prior to the SCOP 1.75 freeze date was dated 2006-10-31, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.76 Å
R-factor: 0.228
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA-(apurinic or apyrimidinic site) lyase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2isia1
  • Chain 'B':
    Compound: DNA-(apurinic or apyrimidinic site) lyase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2isib1
  • Chain 'C':
    Compound: DNA-(apurinic or apyrimidinic site) lyase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2isic1
  • Heterogens: PO4, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2isiA (A:)
pkrgkkgavaedgdelrtepeakksktaakkndkeaagegpalyedppdqktspsgkpat
lkicswnvdglrawikkkgldwvkeeapdilclqetkcsenklpaelqelpglshqywsa
psdkegysgvgllsrqcplkvsygigdeehdqegrvivaefdsfvlvtayvpnagrglvr
leyrqrwdeafrkflkglasrkplvlcgdlnvaheeidlrnpkgnkknagftpqerqgfg
ellqavpladsfrhlypntpyaytfwtymmnarsknvgwrldyfllshsllpalcdskir
skalgsdhcpitlylal

    Sequence, based on observed residues (ATOM records): (download) 
    >2isiA (A:)
alyedppdqktspsgkpatlkicswnvdglrawikkkgldwvkeeapdilclqetkcsen
klpaelqelpglshqywsapsdkegysgvgllsrqcplkvsygigdeehdqegrvivaef
dsfvlvtayvpnagrglvrleyrqrwdeafrkflkglasrkplvlcgdlnvaheeidlrn
pkgnkknagftpqerqgfgellqavpladsfrhlypntpyaytfwtymmnarsknvgwrl
dyfllshsllpalcdskirskalgsdhcpitlylal

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2isiB (B:)
pkrgkkgavaedgdelrtepeakksktaakkndkeaagegpalyedppdqktspsgkpat
lkicswnvdglrawikkkgldwvkeeapdilclqetkcsenklpaelqelpglshqywsa
psdkegysgvgllsrqcplkvsygigdeehdqegrvivaefdsfvlvtayvpnagrglvr
leyrqrwdeafrkflkglasrkplvlcgdlnvaheeidlrnpkgnkknagftpqerqgfg
ellqavpladsfrhlypntpyaytfwtymmnarsknvgwrldyfllshsllpalcdskir
skalgsdhcpitlylal

    Sequence, based on observed residues (ATOM records): (download) 
    >2isiB (B:)
alyedppdqktspsgkpatlkicswnvdglrawikkkgldwvkeeapdilclqetkcsen
klpaelqelpglshqywsapsdkegysgvgllsrqcplkvsygigdeehdqegrvivaef
dsfvlvtayvpnagrglvrleyrqrwdeafrkflkglasrkplvlcgdlnvaheeidlrn
pkgnkknagftpqerqgfgellqavpladsfrhlypntpyaytfwtymmnarsknvgwrl
dyfllshsllpalcdskirskalgsdhcpitlylal

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2isiC (C:)
pkrgkkgavaedgdelrtepeakksktaakkndkeaagegpalyedppdqktspsgkpat
lkicswnvdglrawikkkgldwvkeeapdilclqetkcsenklpaelqelpglshqywsa
psdkegysgvgllsrqcplkvsygigdeehdqegrvivaefdsfvlvtayvpnagrglvr
leyrqrwdeafrkflkglasrkplvlcgdlnvaheeidlrnpkgnkknagftpqerqgfg
ellqavpladsfrhlypntpyaytfwtymmnarsknvgwrldyfllshsllpalcdskir
skalgsdhcpitlylal

    Sequence, based on observed residues (ATOM records): (download) 
    >2isiC (C:)
alyedppdqktspsgkpatlkicswnvdglrawikkkgldwvkeeapdilclqetkcsen
klpaelqelpglshqywsapegysgvgllsrqcplkvsygigdeehdqegrvivaefdsf
vlvtayvpnagrglvrleyrqrwdeafrkflkglasrkplvlcgdlnvaheeidlrnpkg
nkknagftpqerqgfgellqavpladsfrhlypntpyaytfwtymmnarsknvgwrldyf
llshsllpalcdskirskalgsdhcpitlylal