SCOP 1.73: Structural Classification of Proteins

PDB entry 2irw

View 2irw on RCSB PDB site
Description: Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Ether Inhibitor
Class: oxidoreductase
Keywords: HSD1, NADP, inhibitor
Deposited on 2006-10-16, released 2007-01-23
The last revision prior to the SCOP 1.73 freeze date was dated 2007-01-23, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.239
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: HOMO SAPIENS
Gene: HSD11B1
Database cross-references and differences (RAF-indexed):
- Uniprot P28845 (0-263)
  - conflict (246)
Domains in SCOP 1.73: d2irwa1
Chain 'B':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: HOMO SAPIENS
Gene: HSD11B1
Database cross-references and differences (RAF-indexed):
- Uniprot P28845 (0-263)
  - conflict (246)
Domains in SCOP 1.73: d2irwb1
Chain 'C':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: HOMO SAPIENS
Gene: HSD11B1
Database cross-references and differences (RAF-indexed):
- Uniprot P28845 (0-End)
  - conflict (246)
Domains in SCOP 1.73: d2irwc1
Chain 'D':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: HOMO SAPIENS
Gene: HSD11B1
Database cross-references and differences (RAF-indexed):
- Uniprot P28845 (0-263)
  - conflict (246)
Domains in SCOP 1.73: d2irwd1
Chain 'E':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: HOMO SAPIENS
Gene: HSD11B1
Database cross-references and differences (RAF-indexed):
- Uniprot P28845 (0-End)
  - conflict (246)
Domains in SCOP 1.73: d2irwe1
Chain 'F':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: HOMO SAPIENS
Gene: HSD11B1
Database cross-references and differences (RAF-indexed):
- Uniprot P28845 (0-263)
  - conflict (246)
Domains in SCOP 1.73: d2irwf1
Chain 'G':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: HOMO SAPIENS
Gene: HSD11B1
Database cross-references and differences (RAF-indexed):
- Uniprot P28845 (0-263)
  - conflict (246)
Domains in SCOP 1.73: d2irwg1
Chain 'H':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: HOMO SAPIENS
Gene: HSD11B1
Database cross-references and differences (RAF-indexed):
- Uniprot P28845 (0-263)
  - conflict (246)
Domains in SCOP 1.73: d2irwh1
Heterogens: NAP, NN4

PDB Chain Sequences:

Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)

>2irwA (A:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwtt
llirnpsrkileflystsynmdrf

Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)

>2irwB (B:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwtt
llirnpsrkileflystsynmdrf

Chain 'C':
Sequence, based on SEQRES records: (download)

>2irwC (C:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwtt
llirnpsrkileflystsynmdrf

Sequence, based on observed residues (ATOM records): (download)

>2irwC (C:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwtt
llirnpsrkileflyst

Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)

>2irwD (D:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwtt
llirnpsrkileflystsynmdrf

Chain 'E':
Sequence, based on SEQRES records: (download)

>2irwE (E:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwtt
llirnpsrkileflystsynmdrf

Sequence, based on observed residues (ATOM records): (download)

>2irwE (E:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwtt
llirnpsrkileflyst

Chain 'F':
Sequence; same for both SEQRES and ATOM records: (download)

>2irwF (F:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwtt
llirnpsrkileflystsynmdrf

Chain 'G':
Sequence; same for both SEQRES and ATOM records: (download)

>2irwG (G:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwtt
llirnpsrkileflystsynmdrf

Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)

>2irwH (H:)
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwtt
llirnpsrkileflystsynmdrf