PDB entry 2ipg

View 2ipg on RCSB PDB site
Description: Crystal structure of 17alpha-hydroxysteroid dehydrogenase mutant K31A in complex with NADP+ and epi-testosterone
Class: oxidoreductase
Keywords: 17a-HSD, AKR1C21, AKR, aldo-keto reductase, HSD, hydroxysteroid dehydrogenase, open conformation, epi-testosterone, Oxidoreductase
Deposited on 2006-10-12, released 2007-06-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-02-06, with a file datestamp of 2019-02-01.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3(17)alpha-hydroxysteroid dehydrogenase
    Species: Mus musculus [TaxId:10090]
    Gene: Akr1c21
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q91WR5 (0-318)
      • engineered mutation (26)
    Domains in SCOPe 2.08: d2ipga_
  • Chain 'B':
    Compound: 3(17)alpha-hydroxysteroid dehydrogenase
    Species: Mus musculus [TaxId:10090]
    Gene: Akr1c21
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q91WR5 (0-318)
      • engineered mutation (26)
    Domains in SCOPe 2.08: d2ipgb_
  • Heterogens: NAP, FFA, BME, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ipgA (A:)
chcvilndgnfipvlgfgtalplecpaskakeltkiaidagfhhfdsasvyntedhvgea
irskiadgtvrredifytskvwctslhpelvraslerslqklqfdyvdlylihypmalkp
geenfpvdehgklifdrvdlcatweamekckdagltksigvsnfnyrqlemilnkpglky
kpvcnqvechpylnqmklldfckskdivlvaygvlgtqryggwvdqnspvlldepvlgsm
akkynrtpalialryqlqrgivvlntslkeerikenmqvfefqlssedmkvldglnrnmr
yipaaifkghpnwpfldey

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ipgB (B:)
chcvilndgnfipvlgfgtalplecpaskakeltkiaidagfhhfdsasvyntedhvgea
irskiadgtvrredifytskvwctslhpelvraslerslqklqfdyvdlylihypmalkp
geenfpvdehgklifdrvdlcatweamekckdagltksigvsnfnyrqlemilnkpglky
kpvcnqvechpylnqmklldfckskdivlvaygvlgtqryggwvdqnspvlldepvlgsm
akkynrtpalialryqlqrgivvlntslkeerikenmqvfefqlssedmkvldglnrnmr
yipaaifkghpnwpfldey