PDB entry 2imb

View 2imb on RCSB PDB site
Description: Clostridium botulinum Neurotoxin Serotype A Light Chain Inhibited by L-arginine hydroxamate
Class: hydrolase
Keywords: Clostridium botulinum neurotoxin serotype A, protease inhibitors, substrate specificity, substrate switching, HYDROLASE
Deposited on 2006-10-04, released 2007-06-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 2.4099999999999997 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Botulinum neurotoxin A light-chain
    Species: Clostridium botulinum [TaxId:1491]
    Gene: botA, atx, bna
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7B8V4 (20-End)
      • cloning artifact (10-19)
      • conflict (21)
    Domains in SCOPe 2.08: d2imba2, d2imba3
  • Chain 'B':
    Compound: Botulinum neurotoxin A light-chain
    Species: Clostridium botulinum [TaxId:1491]
    Gene: botA, atx, bna
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7B8V4 (20-End)
      • cloning artifact (10-19)
      • conflict (21)
    Domains in SCOPe 2.08: d2imbb2, d2imbb3
  • Heterogens: ZN, AHL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2imbA (A:)
    mgsshhhhhhssglvprgshmqfvnkqfnykdpvngvdiayikipnvgqmqpvkafkihn
    kiwviperdtftnpeegdlnpppeakqvpvsyydstylstdnekdnylkgvtklferiys
    tdlgrmlltsivrgipfwggstidtelkvidtncinviqpdgsyrseelnlviigpsadi
    iqfecksfghevlnltrngygstqyirfspdftfgfeeslevdtnpllgagkfatdpavt
    lahelihaghrlygiainpnrvfkvntnayyemsglevsfeelrtfgghdakfidslqen
    efrlyyynkfkdiastlnkaksivgttaslqymknvfkekyllsedtsgkfsvdklkfdk
    lykmlteiytednfvkffkvlnrktylnfdkavfkinivpkvnytiydgfnlrntnlaan
    fngqnteinnmnftklknftglfe
    

    Sequence, based on observed residues (ATOM records): (download)
    >2imbA (A:)
    ssglvprgshmqfvnkqfnykdpvngvdiayikipvkafkihnkiwviperdtftnpeeg
    dlnppvpvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwggst
    idtelkvidtncinviqpdgsyrseelnlviigpsadiiqfecksfghevlnltrngygs
    tqyirfspdftfgfeeslagkfatdpavtlahelihaghrlygiainpnrvfkevsfeel
    rtfgghdakfidslqenefrlyyynkfkdiastlnkaksivgaslqymknvfkekyllse
    dtsgkfsvdklkfdklykmlteiytednfvkffkvlnrktylnfdkavfkinivpkvnyt
    iydgfnlrntnlaanfngqnteinnmnftklkn
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2imbB (B:)
    mgsshhhhhhssglvprgshmqfvnkqfnykdpvngvdiayikipnvgqmqpvkafkihn
    kiwviperdtftnpeegdlnpppeakqvpvsyydstylstdnekdnylkgvtklferiys
    tdlgrmlltsivrgipfwggstidtelkvidtncinviqpdgsyrseelnlviigpsadi
    iqfecksfghevlnltrngygstqyirfspdftfgfeeslevdtnpllgagkfatdpavt
    lahelihaghrlygiainpnrvfkvntnayyemsglevsfeelrtfgghdakfidslqen
    efrlyyynkfkdiastlnkaksivgttaslqymknvfkekyllsedtsgkfsvdklkfdk
    lykmlteiytednfvkffkvlnrktylnfdkavfkinivpkvnytiydgfnlrntnlaan
    fngqnteinnmnftklknftglfe
    

    Sequence, based on observed residues (ATOM records): (download)
    >2imbB (B:)
    ssglvprgshmqfvnkqfnykdpvngvdiayikipnmqpvkafkihnkiwviperdtftn
    peegdlnppvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwgg
    stidtelkvidtncinviqpdgsyrseelnlviigpsadiiqfecksfghevlnltrngy
    gstqyirfspdftfgfeeslevdtnpllgagkfatdpavtlahelihaghrlygiainpn
    rvevsfeelrtfgghdakfidslqenefrlyyynkfkdiastlnkaksivgttaslqymk
    nvfkekyllsedtsgkfsvdklkfdklykmlteiytednfvkffkvlnrktylnfdkavf
    kinivpkvnytiydgfnlrntnlaanfngqnteinnmnftkl