PDB entry 2ieo
View 2ieo on RCSB PDB site
Description: Crystal structure analysis of HIV-1 protease mutant I84V with a potent non-peptide inhibitor (UIC-94017)
Class: hydrolase
Keywords: HIV-1 protease, mutant, I84V, dimer, inhibitor, UIC-94017, TMC114, darunavir, HYDROLASE
Deposited on
2006-09-19, released
2006-10-03
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-10-18, with a file datestamp of
2017-10-13.
Experiment type: XRAY
Resolution: 1.53 Å
R-factor: N/A
AEROSPACI score: 0.47
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Protease
Species: Human immunodeficiency virus 1 [TaxId:11676]
Gene: GAG, POL
Database cross-references and differences (RAF-indexed):
- Uniprot P03368
- engineered (6)
- engineered (32)
- engineered (62)
- engineered (66)
- engineered (83)
- engineered (94)
Domains in SCOPe 2.08: d2ieoa_ - Chain 'B':
Compound: Protease
Species: Human immunodeficiency virus 1 [TaxId:11676]
Gene: GAG, POL
Database cross-references and differences (RAF-indexed):
- Uniprot P03368 (0-98)
- engineered (6)
- engineered (32)
- engineered (62)
- engineered (66)
- engineered (83)
- engineered (94)
Domains in SCOPe 2.08: d2ieob_ - Heterogens: CL, NA, 017, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>2ieoA (A:)
pqitlwkrplvtikiggqlkealldtgaddtvieemslpgrwkpkmiggiggfikvrqyd
qiiieiaghkaigtvlvgptpvnvigrnlltqigatlnf
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>2ieoB (B:)
pqitlwkrplvtikiggqlkealldtgaddtvieemslpgrwkpkmiggiggfikvrqyd
qiiieiaghkaigtvlvgptpvnvigrnlltqigatlnf