PDB entry 2ieh

View 2ieh on RCSB PDB site
Description: Crystal structure of human kinesin Eg5 in complex with (R)-mon97, a new monastrol-based inhibitor that binds as (R)-enantiomer
Class: hydrolase
Keywords: beta-sheet core, flanked by three alpha-helices on each side
Deposited on 2006-09-19, released 2007-01-23
The last revision prior to the SCOP 1.73 freeze date was dated 2007-01-23, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.234
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kinesin-like protein KIF11
    Species: HOMO SAPIENS
    Gene: KIF11, EG5, KNSL1
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2ieha1
  • Chain 'B':
    Compound: Kinesin-like protein KIF11
    Species: HOMO SAPIENS
    Gene: KIF11, EG5, KNSL1
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2iehb1
  • Heterogens: MG, K, CL, ADP, MOY, PG4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2iehA (A:)
asqpnssakkkeekgkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladks
srktytfdmvfgastkqidvyrsvvcpildevimgynctifaygqtgtgktftmegersp
neeytweedplagiiprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvser
lqmfddprnkrgviikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsv
tihmkettidgeelvkigklnlvdlagsenigrsgavdkrareagninqslltlgrvita
lvertphvpyreskltrilqdslggrtrtsiiatispaslnleetlstleyahrakniln
kpevnqk

    Sequence, based on observed residues (ATOM records): (download) 
    >2iehA (A:)
kgkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladkssrktytfdmvfga
stkqidvyrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplag
iiprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgv
iikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkettidgee
lvkigklnlvdlagseninqslltlgrvitalvertphvpyreskltrilqdslggrtrt
siiatispaslnleetlstleyahraknilnkpe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2iehB (B:)
asqpnssakkkeekgkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladks
srktytfdmvfgastkqidvyrsvvcpildevimgynctifaygqtgtgktftmegersp
neeytweedplagiiprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvser
lqmfddprnkrgviikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsv
tihmkettidgeelvkigklnlvdlagsenigrsgavdkrareagninqslltlgrvita
lvertphvpyreskltrilqdslggrtrtsiiatispaslnleetlstleyahrakniln
kpevnqk

    Sequence, based on observed residues (ATOM records): (download) 
    >2iehB (B:)
gkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladkssrktytfdmvfgas
tkqidvyrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplagi
iprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgvi
ikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkettidgeel
vkigklnlvdlagseninqslltlgrvitalvertphvpyreskltrilqdslggrtrts
iiatispaslnleetlstleyahraknilnkpevn