PDB entry 2id4

View 2id4 on RCSB PDB site
Description: The 1.9 A structure of Kex2 in complex with an Ac-R-E-R-K-chloromethyl ketone inhibitor.
Class: Hydrolase
Keywords: kex2, kexin, furin, proprotein, prohormone, convertase, subtilisin like protease, serine protease
Deposited on 2006-09-14, released 2007-05-01
The last revision prior to the SCOP 1.73 freeze date was dated 2007-05-01, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.179
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kexin
    Species: Saccharomyces cerevisiae
    Gene: KEX2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13134
      • modified residue (76)
    Domains in SCOP 1.73: d2id4a1, d2id4a2
  • Chain 'B':
    Compound: Kexin
    Species: Saccharomyces cerevisiae
    Gene: KEX2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13134
      • modified residue (76)
    Domains in SCOP 1.73: d2id4b1, d2id4b2
  • Chain 'C':
    Compound: Ac-RERK-CMK inhibitor
    Species: synthetic, synthetic
  • Chain 'D':
    Compound: Ac-RERK-CMK inhibitor
    Species: synthetic, synthetic
  • Heterogens: NAG, CA, NA, MLA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2id4A (A:)
appmdssllpvkeaedklsindplferqwhlvnpsfpgsdinvldlwynnitgagvvaai
vddgldyenedlkdnfcaegswdfndntnlpkprlsddyhgtrcageiaakkgnnfcgvg
vgynakisgirilsgdittedeaasliygldvndiyscswgpaddgrhlqgpsdlvkkal
vkgvtegrdskgaiyvfasgnggtrgdncnydgytnsiysitigaidhkdlhppysegcs
avmavtyssgsgeyihssdingrcsnshggtsaaaplaagvytllleanpnltwrdvqyl
silsavgleknadgdwrdsamgkkyshrygfgkidahkliemsktwenvnaqtwfylptl
yvsqstnsteetlesvitisekslqdanfkriehvtvtvdidteirgtttvdlispagii
snlgvvrprdvssegfkdwtfmsvahwgengvgdwkikvkttenghridfhswrlklfge
sidssktetfvfgndkeeverqr

    Sequence, based on observed residues (ATOM records): (download) 
    >2id4A (A:)
lpvkeaedklsindplferqwhlvnpsfpgsdinvldlwynnitgagvvaaivddgldye
nedlkdnfcaegswdfndntnlpkprlsddyhgtrcageiaakkgnnfcgvgvgynakis
girilsgdittedeaasliygldvndiyscswgpaddgrhlqgpsdlvkkalvkgvtegr
dskgaiyvfasgnggtrgdncnydgytnsiysitigaidhkdlhppysegcsavmavtys
sgsgeyihssdingrcsnshggtsaaaplaagvytllleanpnltwrdvqylsilsavgl
eknadgdwrdsamgkkyshrygfgkidahkliemsktwenvnaqtwfylptlyvsqstns
teetlesvitisekslqdanfkriehvtvtvdidteirgtttvdlispagiisnlgvvrp
rdvssegfkdwtfmsvahwgengvgdwkikvkttenghridfhswrlklfgesidsskte

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2id4B (B:)
appmdssllpvkeaedklsindplferqwhlvnpsfpgsdinvldlwynnitgagvvaai
vddgldyenedlkdnfcaegswdfndntnlpkprlsddyhgtrcageiaakkgnnfcgvg
vgynakisgirilsgdittedeaasliygldvndiyscswgpaddgrhlqgpsdlvkkal
vkgvtegrdskgaiyvfasgnggtrgdncnydgytnsiysitigaidhkdlhppysegcs
avmavtyssgsgeyihssdingrcsnshggtsaaaplaagvytllleanpnltwrdvqyl
silsavgleknadgdwrdsamgkkyshrygfgkidahkliemsktwenvnaqtwfylptl
yvsqstnsteetlesvitisekslqdanfkriehvtvtvdidteirgtttvdlispagii
snlgvvrprdvssegfkdwtfmsvahwgengvgdwkikvkttenghridfhswrlklfge
sidssktetfvfgndkeeverqr

    Sequence, based on observed residues (ATOM records): (download) 
    >2id4B (B:)
lpvkeaedklsindplferqwhlvnpsfpgsdinvldlwynnitgagvvaaivddgldye
nedlkdnfcaegswdfndntnlpkprlsddyhgtrcageiaakkgnnfcgvgvgynakis
girilsgdittedeaasliygldvndiyscswgpaddgrhlqgpsdlvkkalvkgvtegr
dskgaiyvfasgnggtrgdncnydgytnsiysitigaidhkdlhppysegcsavmavtys
sgsgeyihssdingrcsnshggtsaaaplaagvytllleanpnltwrdvqylsilsavgl
eknadgdwrdsamgkkyshrygfgkidahkliemsktwenvnaqtwfylptlyvsqstns
teetlesvitisekslqdanfkriehvtvtvdidteirgtttvdlispagiisnlgvvrp
rdvssegfkdwtfmsvahwgengvgdwkikvkttenghridfhswrlklfgesidsskt

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.