PDB entry 2ian

View 2ian on RCSB PDB site
Description: Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR
Class: immune system
Keywords: X-ray crystallography, major histocompatibility complex, T cell receptor, T cell stimulation, melanoma, tumor antigen, IMMUNE SYSTEM
Deposited on 2006-09-08, released 2007-04-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.225
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2iana1, d2iana2, d2iana3
  • Chain 'B':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ianb1, d2ianb2
  • Chain 'C':
    Compound: 15-mer peptide from Triosephosphate isomerase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPI1, TPI
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: CD4+ T cell receptor E8 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2iand1, d2iand2
  • Chain 'E':
    Compound: CD4+ T cell receptor E8 beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2iane1, d2iane2
  • Chain 'F':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ianf1, d2ianf2
  • Chain 'G':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2iang1, d2iang2
  • Chain 'H':
    Compound: 15-mer peptide from Triosephosphate isomerase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPI1, TPI
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: CD4+ T cell receptor E8 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2iani1, d2iani2
  • Chain 'J':
    Compound: CD4+ T cell receptor E8 beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ianj1, d2ianj2
  • Chain 'K':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2iank1, d2iank2
  • Chain 'L':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ianl1, d2ianl2
  • Chain 'M':
    Compound: 15-mer peptide from Triosephosphate isomerase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPI1, TPI
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: CD4+ T cell receptor E8 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2iann1, d2iann2
  • Chain 'O':
    Compound: CD4+ T cell receptor E8 beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2iano1, d2iano2
  • Chain 'P':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ianp1, d2ianp2
  • Chain 'Q':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ianq1, d2ianq2
  • Chain 'R':
    Compound: 15-mer peptide from Triosephosphate isomerase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPI1, TPI
    Database cross-references and differences (RAF-indexed):
  • Chain 'S':
    Compound: CD4+ T cell receptor E8 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ians1, d2ians2
  • Chain 'T':
    Compound: CD4+ T cell receptor E8 beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2iant1, d2iant2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ianA (A:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianA (A:)
ehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalani
avdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwlr
ngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ianB (B:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
tspltvewra

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianB (B:)
trprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeywn
sqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypshnllvcsvsgfypgsiev
rwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvtspltvewr
a

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2ianD (D:)
iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
ttvaterysllyisssqttdsgvyfcaaliqgaqklvfgqgtrltinpniqnpdpavyql
rdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfa
canafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianD (D:)
iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
ttvaterysllyisssqttdsgvyfcaaliqgaqklvfgqgtrltinpniqnpdpavyql
rdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfa
canafnnsiipedtffps

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2ianE (E:)
nagvtqtpkfrilkigqsmtlqctqdmnhnymywyrqdpgmglkliyysvgagitdkgev
pngynvsrsttedfplrlelaapsqtsvyfcastyhgtgyfgegswltvvedlnkvfppe
vavfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvctdpqplkeqpaln
dsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianE (E:)
gvtqtpkfrilkigqsmtlqctqdmnhnymywyrqdpgmglkliyysvgagitdkgevpn
gynvsrsttedfplrlelaapsqtsvyfcastyhgtgyfgegswltvvedlnkvfppeva
vfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvctdpqplkeqpalnds
ryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2ianF (F:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianF (F:)
eehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalan
iavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwl
rngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >2ianG (G:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
tspltvewra

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianG (G:)
dtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeyw
nsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypshnllvcsvsgfypgsie
vrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvtspltvew
ra

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >2ianI (I:)
iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
ttvaterysllyisssqttdsgvyfcaaliqgaqklvfgqgtrltinpniqnpdpavyql
rdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfa
canafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianI (I:)
iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
ttvaterysllyisssqttdsgvyfcaaliqgaqklvfgqgtrltinpniqnpdpavyql
rdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfa
canafnnsiipedtffps

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >2ianJ (J:)
nagvtqtpkfrilkigqsmtlqctqdmnhnymywyrqdpgmglkliyysvgagitdkgev
pngynvsrsttedfplrlelaapsqtsvyfcastyhgtgyfgegswltvvedlnkvfppe
vavfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvctdpqplkeqpaln
dsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianJ (J:)
agvtqtpkfrilkigqsmtlqctqdmnhnymywyrqdpgmglkliyysvgagitdkgevp
ngynvsrsttedfplrlelaapsqtsvyfcastyhgtgyfgegswltvvedlnkvfppev
avfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvctdpqplkeqpalnd
sryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >2ianK (K:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianK (K:)
eehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalan
iavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwl
rngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >2ianL (L:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
tspltvewra

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianL (L:)
trprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeywn
sqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvsgf
ypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvts
pltvewra

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >2ianN (N:)
iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
ttvaterysllyisssqttdsgvyfcaaliqgaqklvfgqgtrltinpniqnpdpavyql
rdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfa
canafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianN (N:)
iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
ttvaterysllyisssqttdsgvyfcaaliqgaqklvfgqgtrltinpniqnpdpavyql
rdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfa
canafnnsiipedtffps

  • Chain 'O':
    Sequence, based on SEQRES records: (download) 
    >2ianO (O:)
nagvtqtpkfrilkigqsmtlqctqdmnhnymywyrqdpgmglkliyysvgagitdkgev
pngynvsrsttedfplrlelaapsqtsvyfcastyhgtgyfgegswltvvedlnkvfppe
vavfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvctdpqplkeqpaln
dsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianO (O:)
gvtqtpkfrilkigqsmtlqctqdmnhnymywyrqdpgmglkliyysvgagitdkgevpn
gynvsrsttedfplrlelaapsqtsvyfcastyhgtgyfgegswltvvedlnkvfppeva
vfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvctdpqplkeqpalnds
ryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad

  • Chain 'P':
    Sequence, based on SEQRES records: (download) 
    >2ianP (P:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianP (P:)
eehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalan
iavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwl
rngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd

  • Chain 'Q':
    Sequence, based on SEQRES records: (download) 
    >2ianQ (Q:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
tspltvewra

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianQ (Q:)
trprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeywn
sqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvsgf
ypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvts
pltvewra

  • Chain 'R':
    No sequence available.

  • Chain 'S':
    Sequence, based on SEQRES records: (download) 
    >2ianS (S:)
iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
ttvaterysllyisssqttdsgvyfcaaliqgaqklvfgqgtrltinpniqnpdpavyql
rdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfa
canafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianS (S:)
iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
ttvaterysllyisssqttdsgvyfcaaliqgaqklvfgqgtrltinpniqnpdpavyql
rdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfa
canafnnsiipedtffps

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >2ianT (T:)
nagvtqtpkfrilkigqsmtlqctqdmnhnymywyrqdpgmglkliyysvgagitdkgev
pngynvsrsttedfplrlelaapsqtsvyfcastyhgtgyfgegswltvvedlnkvfppe
vavfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvctdpqplkeqpaln
dsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >2ianT (T:)
gvtqtpkfrilkigqsmtlqctqdmnhnymywyrqdpgmglkliyysvgagitdkgevpn
gynvsrsttedfplrlelaapsqtsvyfcastyhgtgyfgegswltvvedlnkvfppeva
vfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvctdpqplkeqpalnds
ryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad