PDB entry 2iam
View 2iam on RCSB PDB site
Description: Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR
Class: immune system
Keywords: X-ray crystallography, major histocompatibility complex, T cell receptor, T cell stimulation, melanoma, tumor antigen, IMMUNE SYSTEM
Deposited on
2006-09-08, released
2007-04-03
The last revision prior to the SCOPe 2.06 freeze date was dated
2009-02-24, with a file datestamp of
2009-02-03.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.211
AEROSPACI score: 0.25
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: hla class II histocompatibility antigen, dr alpha chain
Species: Homo sapiens [TaxId:9606]
Gene: HLA-DRA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2iama1, d2iama2 - Chain 'B':
Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
Species: Homo sapiens [TaxId:9606]
Gene: HLA-DRB1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2iamb1, d2iamb2 - Chain 'C':
Compound: CD4+ T cell receptor E8 alpha chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2iamc1, d2iamc2 - Chain 'D':
Compound: CD4+ T cell receptor E8 beta chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2iamd1, d2iamd2 - Chain 'P':
Compound: 15-mer peptide from Triosephosphate isomerase
Species: Homo sapiens [TaxId:9606]
Gene: TPI1, TPI
Database cross-references and differences (RAF-indexed):
- Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2iamA (A:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da
Sequence, based on observed residues (ATOM records): (download)
>2iamA (A:)
eehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalan
iavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwl
rngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2iamB (B:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
tspltvewra
Sequence, based on observed residues (ATOM records): (download)
>2iamB (B:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsnllvcsvsgfypgsie
vrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvtspltvew
ra
- Chain 'C':
Sequence, based on SEQRES records: (download)
>2iamC (C:)
iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
ttvaterysllyisssqttdsgvyfcaaliqgaqklvfgqgtrltinpniqnpdpavyql
rdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfa
canafnnsiipedtffpspess
Sequence, based on observed residues (ATOM records): (download)
>2iamC (C:)
iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
ttvaterysllyisssqttdsgvyfcaaliqgaqklvfgqgtrltinpniqnpdpavyql
rdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfa
canafnnsiipedtffps
- Chain 'D':
Sequence, based on SEQRES records: (download)
>2iamD (D:)
nagvtqtpkfrilkigqsmtlqctqdmnhnymywyrqdpgmglkliyysvgagitdkgev
pngynvsrsttedfplrlelaapsqtsvyfcastyhgtgyfgegswltvvedlnkvfppe
vavfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvctdpqplkeqpaln
dsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad
Sequence, based on observed residues (ATOM records): (download)
>2iamD (D:)
agvtqtpkfrilkigqsmtlqctqdmnhnymywyrqdpgmglkliyysvgagitdkgevp
ngynvsrsttedfplrlelaapsqtsvyfcastyhgtgyfgegswltvvedlnkvfppev
avfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvctdpqplkeqpalnd
sryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad
- Chain 'P':
No sequence available.