PDB entry 2iam

View 2iam on RCSB PDB site
Description: Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR
Class: immune system
Keywords: X-ray crystallography, major histocompatibility complex, T cell receptor, T cell stimulation, melanoma, tumor antigen, IMMUNE SYSTEM
Deposited on 2006-09-08, released 2007-04-03
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.211
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2iama1, d2iama2
  • Chain 'B':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2iamb1, d2iamb2
  • Chain 'C':
    Compound: CD4+ T cell receptor E8 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2iamc1, d2iamc2
  • Chain 'D':
    Compound: CD4+ T cell receptor E8 beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2iamd1, d2iamd2
  • Chain 'P':
    Compound: 15-mer peptide from Triosephosphate isomerase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPI1, TPI
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60174 (0-14)
      • engineered (5)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2iamA (A:)
    ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
    aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
    wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
    da
    

    Sequence, based on observed residues (ATOM records): (download)
    >2iamA (A:)
    eehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalan
    iavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwl
    rngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2iamB (B:)
    gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
    wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
    gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
    tspltvewra
    

    Sequence, based on observed residues (ATOM records): (download)
    >2iamB (B:)
    gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
    wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsnllvcsvsgfypgsie
    vrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvtspltvew
    ra
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2iamC (C:)
    iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
    ttvaterysllyisssqttdsgvyfcaaliqgaqklvfgqgtrltinpniqnpdpavyql
    rdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfa
    canafnnsiipedtffpspess
    

    Sequence, based on observed residues (ATOM records): (download)
    >2iamC (C:)
    iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
    ttvaterysllyisssqttdsgvyfcaaliqgaqklvfgqgtrltinpniqnpdpavyql
    rdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfa
    canafnnsiipedtffps
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >2iamD (D:)
    nagvtqtpkfrilkigqsmtlqctqdmnhnymywyrqdpgmglkliyysvgagitdkgev
    pngynvsrsttedfplrlelaapsqtsvyfcastyhgtgyfgegswltvvedlnkvfppe
    vavfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvctdpqplkeqpaln
    dsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad
    

    Sequence, based on observed residues (ATOM records): (download)
    >2iamD (D:)
    agvtqtpkfrilkigqsmtlqctqdmnhnymywyrqdpgmglkliyysvgagitdkgevp
    ngynvsrsttedfplrlelaapsqtsvyfcastyhgtgyfgegswltvvedlnkvfppev
    avfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvctdpqplkeqpalnd
    sryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad
    

  • Chain 'P':
    No sequence available.