PDB entry 2i9p

View 2i9p on RCSB PDB site
Description: Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+
Class: oxidoreductase
Keywords: 3-hydroxyacid dehydrogenase, Structural Genomics, Structural Genomics Consortium, SGC, OXIDOREDUCTASE
Deposited on 2006-09-06, released 2006-09-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-31, with a file datestamp of 2018-01-26.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-hydroxyisobutyrate dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: HIBADH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31937 (23-End)
      • cloning artifact (22)
    Domains in SCOPe 2.08: d2i9pa1, d2i9pa2, d2i9pa3
  • Chain 'B':
    Compound: 3-hydroxyisobutyrate dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: HIBADH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31937 (23-End)
      • cloning artifact (22)
    Domains in SCOPe 2.08: d2i9pb1, d2i9pb2, d2i9pb3
  • Chain 'C':
    Compound: 3-hydroxyisobutyrate dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: HIBADH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31937 (23-End)
      • cloning artifact (22)
    Domains in SCOPe 2.08: d2i9pc1, d2i9pc2, d2i9pc3
  • Chain 'D':
    Compound: 3-hydroxyisobutyrate dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: HIBADH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31937 (23-End)
      • cloning artifact (22)
    Domains in SCOPe 2.08: d2i9pd1, d2i9pd2, d2i9pd3
  • Heterogens: NAD

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2i9pA (A:)
mhhhhhhssgvdlgtenlyfqsmpvgfiglgnmgnpmaknlmkhgypliiydvfpdacke
fqdageqvvsspadvaekadriitmlptsinaieaysgangilkkvkkgsllidsstidp
avskelakevekmgavfmdapvsggvgaarsgnltfmvggvedefaaaqellgcmgsnvv
ycgavgtgqaakicnnmllaismigtaeamnlgirlgldpkllakilnmssgrcwssdty
npvpgvmdgvpsannyqggfgttlmakdlglaqdsatstkspillgslahqiyrmmcakg
yskkdfssvfqflreeetf

    Sequence, based on observed residues (ATOM records): (download) 
    >2i9pA (A:)
mpvgfiglgnmgnpmaknlmkhgypliiydvfpdackefqdageqvvsspadvaekadri
itmlptsinaieaysgangilkkvkkgsllidsstidpavskelakevekmgavfmdapv
sggvgaarsgnltfmvggvedefaaaqellgcmgsnvvycgavgtgqaakicnnmllais
migtaeamnlgirlgldpkllakilnmssgrcwssdtynpvpgvmdgvpsannyqggfgt
tlmakdlglaqdsatstkspillgslahqiyrmmcakgyskkdfssvfqflre

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2i9pB (B:)
mhhhhhhssgvdlgtenlyfqsmpvgfiglgnmgnpmaknlmkhgypliiydvfpdacke
fqdageqvvsspadvaekadriitmlptsinaieaysgangilkkvkkgsllidsstidp
avskelakevekmgavfmdapvsggvgaarsgnltfmvggvedefaaaqellgcmgsnvv
ycgavgtgqaakicnnmllaismigtaeamnlgirlgldpkllakilnmssgrcwssdty
npvpgvmdgvpsannyqggfgttlmakdlglaqdsatstkspillgslahqiyrmmcakg
yskkdfssvfqflreeetf

    Sequence, based on observed residues (ATOM records): (download) 
    >2i9pB (B:)
mpvgfiglgnmgnpmaknlmkhgypliiydvfpdackefqdageqvvsspadvaekadri
itmlptsinaieaysgangilkkvkkgsllidsstidpavskelakevekmgavfmdapv
sggvgaarsgnltfmvggvedefaaaqellgcmgsnvvycgavgtgqaakicnnmllais
migtaeamnlgirlgldpkllakilnmssgrcwssdtynpvpgvmdgvpsannyqggfgt
tlmakdlglaqdsatstkspillgslahqiyrmmcakgyskkdfssvfqflreeet

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2i9pC (C:)
mhhhhhhssgvdlgtenlyfqsmpvgfiglgnmgnpmaknlmkhgypliiydvfpdacke
fqdageqvvsspadvaekadriitmlptsinaieaysgangilkkvkkgsllidsstidp
avskelakevekmgavfmdapvsggvgaarsgnltfmvggvedefaaaqellgcmgsnvv
ycgavgtgqaakicnnmllaismigtaeamnlgirlgldpkllakilnmssgrcwssdty
npvpgvmdgvpsannyqggfgttlmakdlglaqdsatstkspillgslahqiyrmmcakg
yskkdfssvfqflreeetf

    Sequence, based on observed residues (ATOM records): (download) 
    >2i9pC (C:)
mpvgfiglgnmgnpmaknlmkhgypliiydvfpdackefqdageqvvsspadvaekadri
itmlptsinaieaysgangilkkvkkgsllidsstidpavskelakevekmgavfmdapv
sggvgaarsgnltfmvggvedefaaaqellgcmgsnvvycgavgtgqaakicnnmllais
migtaeamnlgirlgldpkllakilnmssgrcwssdtynpvpgvmdgvpsannyqggfgt
tlmakdlglaqdsatstkspillgslahqiyrmmcakgyskkdfssvfqflre

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2i9pD (D:)
mhhhhhhssgvdlgtenlyfqsmpvgfiglgnmgnpmaknlmkhgypliiydvfpdacke
fqdageqvvsspadvaekadriitmlptsinaieaysgangilkkvkkgsllidsstidp
avskelakevekmgavfmdapvsggvgaarsgnltfmvggvedefaaaqellgcmgsnvv
ycgavgtgqaakicnnmllaismigtaeamnlgirlgldpkllakilnmssgrcwssdty
npvpgvmdgvpsannyqggfgttlmakdlglaqdsatstkspillgslahqiyrmmcakg
yskkdfssvfqflreeetf

    Sequence, based on observed residues (ATOM records): (download) 
    >2i9pD (D:)
mpvgfiglgnmgnpmaknlmkhgypliiydvfpdackefqdageqvvsspadvaekadri
itmlptsinaieaysgangilkkvkkgsllidsstidpavskelakevekmgavfmdapv
sggvgaarsgnltfmvggvedefaaaqellgcmgsnvvycgavgtgqaakicnnmllais
migtaeamnlgirlgldpkllakilnmssgrcwssdtynpvpgvmdgvpsannyqggfgt
tlmakdlglaqdsatstkspillgslahqiyrmmcakgyskkdfssvfqflre