PDB entry 2i5x

View 2i5x on RCSB PDB site
Description: Engineering the PTPbeta catalytic domain with improved crystallization properties
Class: hydrolase
Keywords: protein tyrosine phosphatase, WPD-loop, drug design, protein engineering, HYDROLASE
Deposited on 2006-08-26, released 2006-09-05
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.18
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor-type tyrosine-protein phosphatase beta
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPRB, PTPB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2i5xa_
  • Chain 'B':
    Compound: Receptor-type tyrosine-protein phosphatase beta
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPRB, PTPB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2i5xb_
  • Heterogens: MG, CL, UA5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2i5xA (A:)
sdrplsvhlnlgqkgnrktscpikinqfeghfmklqadsnyllskeyeelkdvgrnqscd
iallpenrgknrynnilpydatrvklsnvdddpcsdyinasyipgnnfrreyivtqgplp
gtkddfwkmvweqnvhnivmvtqcvekgrvkcdhywpadqdslyygdlilqmlsesvlpe
wtirefkicgeeqldahrlirhfhytvwpdhgvpettqsliqfvrtvrdyinrspgagpt
vvhcsagvgrtgtfialdrilqqldskdsvdiygavhdlrlhrvhmvqtecqyvylhqcv
rdvlrarklrseq

    Sequence, based on observed residues (ATOM records): (download) 
    >2i5xA (A:)
ktscpikinqfeghfmklqadsnyllskeyeelkdvgrnqscdiallpenrgknrynnil
pydatrvklsnpcsdyinasyipgnnfrreyivtqgplpgtkddfwkmvweqnvhnivmv
tqcvekgrvkcdhywpadqdslyygdlilqmlsesvlpewtirefkicghrlirhfhytv
wpdhgvpettqsliqfvrtvrdyinrspgagptvvhcsagvgrtgtfialdrilqqldsk
dsvdiygavhdlrlhrvhmvqtecqyvylhqcvrdvlrar

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2i5xB (B:)
sdrplsvhlnlgqkgnrktscpikinqfeghfmklqadsnyllskeyeelkdvgrnqscd
iallpenrgknrynnilpydatrvklsnvdddpcsdyinasyipgnnfrreyivtqgplp
gtkddfwkmvweqnvhnivmvtqcvekgrvkcdhywpadqdslyygdlilqmlsesvlpe
wtirefkicgeeqldahrlirhfhytvwpdhgvpettqsliqfvrtvrdyinrspgagpt
vvhcsagvgrtgtfialdrilqqldskdsvdiygavhdlrlhrvhmvqtecqyvylhqcv
rdvlrarklrseq

    Sequence, based on observed residues (ATOM records): (download) 
    >2i5xB (B:)
ktscpikinqfeghfmklqadsnyllskeyeelkdvgrnqscdiallpenrgknrynnil
pydatrvklsncsdyinasyipgnnfrreyivtqgplpgtkddfwkmvweqnvhnivmvt
qcvekgrvkcdhywpadqdslyygdlilqmlsesvlpewtirefkicghrlirhfhytvw
pdhgvpettqsliqfvrtvrdyinrspgagptvvhcsagvgrtgtfialdrilqqldskd
svdiygavhdlrlhrvhmvqtecqyvylhqcvrdvlrarkl