PDB entry 2i47

View 2i47 on RCSB PDB site
Description: Crystal structure of catalytic domain of TACE with inhibitor
Class: hydrolase
Keywords: TACE/ADAM-17, TACE-inhibitor complex, hydrolase
Deposited on 2006-08-21, released 2006-12-05
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.198
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: adam 17
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P78536
      • engineered (54)
      • engineered (240)
    Domains in SCOPe 2.06: d2i47a_
  • Chain 'B':
    Compound: adam 17
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P78536
      • engineered (54)
      • engineered (240)
    Domains in SCOPe 2.06: d2i47b_
  • Chain 'C':
    Compound: adam 17
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P78536
      • engineered (54)
      • engineered (240)
    Domains in SCOPe 2.06: d2i47c_
  • Chain 'D':
    Compound: adam 17
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P78536
      • engineered (54)
      • engineered (240)
    Domains in SCOPe 2.06: d2i47d_
  • Heterogens: ZN, INN, KGY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2i47A (A:)
vkrradpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnag
fkgygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeask
vclahlftyqdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknyg
ktiltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfs
qcskqsiyktieskaqecfqersnkvcgnsrvdegeecdpgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2i47A (A:)
pmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgygiqi
eqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclahlft
yqdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknygktiltkea
dlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskqsiy
ktieskaqecfqers

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2i47B (B:)
vkrradpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnag
fkgygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeask
vclahlftyqdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknyg
ktiltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfs
qcskqsiyktieskaqecfqersnkvcgnsrvdegeecdpgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2i47B (B:)
mkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgygiqie
qirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclahlfty
qdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknygktiltkead
lvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskqsiyk
tieskaqecfqers

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2i47C (C:)
vkrradpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnag
fkgygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeask
vclahlftyqdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknyg
ktiltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfs
qcskqsiyktieskaqecfqersnkvcgnsrvdegeecdpgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2i47C (C:)
mkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgygiqie
qirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclahlfty
qdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknygktiltkead
lvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskqsiyk
tieskaqecfqers

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2i47D (D:)
vkrradpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnag
fkgygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeask
vclahlftyqdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknyg
ktiltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfs
qcskqsiyktieskaqecfqersnkvcgnsrvdegeecdpgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2i47D (D:)
pmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgygiqi
eqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclahlft
yqdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknygktiltkea
dlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskqsiy
ktieskaqecfqers