PDB entry 2i3r

View 2i3r on RCSB PDB site
Description: Engineered catalytic domain of protein tyrosine phosphatase HPTPbeta
Class: hydrolase
Keywords: protein tyrosine phosphatase, WPD-loop, sulfamic acid, phosphatase, inhibitor, drug design, HYDROLASE
Deposited on 2006-08-20, released 2006-08-29
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.184
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor-type tyrosine-protein phosphatase beta
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPRB, PTPB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2i3ra_
  • Chain 'B':
    Compound: Receptor-type tyrosine-protein phosphatase beta
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPRB, PTPB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2i3rb_
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2i3rA (A:)
sdrplsvhlnlgqkgnrktscpikinqfeghfmklqadsnyllskeyeelkdvgrnqscd
iallpenrgknrynnilpydatrvklsnvdddpcsdyinasyipgnnfrreyivtqgplp
gtkddfwkmvweqnvhnivmvtqcvekgrvkcdhywpadqdslyygdlilqmlsesvlpe
wtirefkicgeeqldahrlirhfhytvwpdhgvpettqsliqfvrtvrdyinrspgagpt
vvhcsagvgrtgtfialdrilqqldskdsvdiygavhdlrlhrvhmvqtecqyvylhqcv
rdvlrarklrseq

    Sequence, based on observed residues (ATOM records): (download) 
    >2i3rA (A:)
tscpikinqfeghfmklqadsnyllskeyeelkdvgrnqscdiallpenrgknrynnilp
ydatrvklsnvdddpcsdyinasyipgnnfrreyivtqgplpgtkddfwkmvweqnvhni
vmvtqcvekgrvkcdhywpadqdslyygdlilqmlsesvlpewtirefkicgahrlirhf
hytvwpdhgvpettqsliqfvrtvrdyinrspgagptvvhcsagvgrtgtfialdrilqq
ldskdsvdiygavhdlrlhrvhmvqtecqyvylhqcvrdvlrarkl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2i3rB (B:)
sdrplsvhlnlgqkgnrktscpikinqfeghfmklqadsnyllskeyeelkdvgrnqscd
iallpenrgknrynnilpydatrvklsnvdddpcsdyinasyipgnnfrreyivtqgplp
gtkddfwkmvweqnvhnivmvtqcvekgrvkcdhywpadqdslyygdlilqmlsesvlpe
wtirefkicgeeqldahrlirhfhytvwpdhgvpettqsliqfvrtvrdyinrspgagpt
vvhcsagvgrtgtfialdrilqqldskdsvdiygavhdlrlhrvhmvqtecqyvylhqcv
rdvlrarklrseq

    Sequence, based on observed residues (ATOM records): (download) 
    >2i3rB (B:)
tscpikinqfeghfmklqadsnyllskeyeelkdvgrnqscdiallpenrgknrynnilp
ydatrvklscsdyinasyipgnnfrreyivtqgplpgtkddfwkmvweqnvhnivmvtqc
vekgrvkcdhywpadqdslyygdlilqmlsesvlpewtirefkicgrlirhfhytvwpdh
gvpettqsliqfvrtvrdyinrspgagptvvhcsagvgrtgtfialdrilqqldskdsvd
iygavhdlrlhrvhmvqtecqyvylhqcvrdvlrarkl