PDB entry 2i3h
View 2i3h on RCSB PDB site
Description: Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW)
Class: inhibitor/apoptosis
Keywords: zinc binding, peptide complex, apoptosis inhibition, peptidomimetic, small molecule, drug design, inhibitor/apoptosis complex
Deposited on
2006-08-18, released
2006-09-19
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 1.62 Å
R-factor: 0.162
AEROSPACI score: 0.61
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Baculoviral IAP repeat-containing protein 7
Species: Homo sapiens [TaxId:9606]
Gene: BIRC7
Database cross-references and differences (RAF-indexed):
- Uniprot Q96CA5
- see remark 999 (110)
- see remark 999 (120-127)
Domains in SCOPe 2.08: d2i3ha1 - Chain 'B':
Compound: Baculoviral IAP repeat-containing protein 7
Species: Homo sapiens [TaxId:9606]
Gene: BIRC7
Database cross-references and differences (RAF-indexed):
- Uniprot Q96CA5 (Start-132)
- see remark 999 (110)
- see remark 999 (120-128)
- see remark 999 (132)
Domains in SCOPe 2.08: d2i3hb1 - Chain 'C':
Compound: AVPW peptide
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: AVPW peptide
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Heterogens: ZN, LI, BTB, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2i3hA (A:)
mgsshhhhhhssgevprgshmleteeeeeegagatlsrgpafpgmgseelrlasfydwpl
taevppellaaagffhtghqdkvrcffcygglqswkrgddpwtehakwfpgcqfllrskg
qeyinnihlthsl
Sequence, based on observed residues (ATOM records): (download)
>2i3hA (A:)
gpafpgmgseelrlasfydwpltaevppellaaagffhtghqdkvrcffcygglqswkrg
ddpwtehakwfpgcqfllrskgqeyinnih
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2i3hB (B:)
mgsshhhhhhssgevprgshmleteeeeeegagatlsrgpafpgmgseelrlasfydwpl
taevppellaaagffhtghqdkvrcffcygglqswkrgddpwtehakwfpgcqfllrskg
qeyinnihlthsl
Sequence, based on observed residues (ATOM records): (download)
>2i3hB (B:)
gpafpgmgseelrlasfydwpltaevppellaaagffhtghqdkvrcffcygglqswkrg
ddpwtehakwfpgcqfllrskgqeyinnihlthsl
- Chain 'C':
No sequence available.
- Chain 'D':
No sequence available.