PDB entry 2i3c

View 2i3c on RCSB PDB site
Description: Crystal Structure of an Aspartoacylase from Homo Sapiens
Class: hydrolase
Keywords: Canavan disease, N-acetyl-L-aspartate, Zinc-dependent hydrolase, Aspartoacylase family, Aminoacylase-2, ACY2, ASPA, PROTEIN STRUCTURE INITIATIVE, PSI, CENTER FOR EUKARYOTIC STRUCTURAL GENOMICS, CESG
Deposited on 2006-08-17, released 2006-08-29
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.197
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aspartoacylase
    Species: Homo sapiens [TaxId:9606]
    Gene: ASPA, ACY2, ASP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P45381
      • modified residue (83)
      • modified residue (123)
      • modified residue (140)
      • modified residue (196)
      • modified residue (199)
      • modified residue (262)
    Domains in SCOPe 2.01: d2i3ca1
  • Chain 'B':
    Compound: Aspartoacylase
    Species: Homo sapiens [TaxId:9606]
    Gene: ASPA, ACY2, ASP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P45381
      • modified residue (83)
      • modified residue (123)
      • modified residue (140)
      • modified residue (196)
      • modified residue (199)
      • modified residue (262)
    Domains in SCOPe 2.01: d2i3cb_
  • Heterogens: ZN, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2i3cA (A:)
aiatschiaeehiqkvaifggthgneltgvflvkhwlengaeiqrtglevkpfitnprav
kkctryidcdlnrifdlenlgkkmsedlpyevrraqeinhlfgpkdsedsydiifdlhnt
tsnmgctliledsrnnfliqmfhyiktslaplpcyvyliehpslkyattrsiakypvgie
vgpqpqgvlradildqmrkmikhaldfihhfnegkefppcaievykiiekvdyprdenge
iaaiihpnlqdqdwkplhpgdpmfltldgktiplggdctvypvfvneaayyekkeafakt
tkltlnaksircclh

    Sequence, based on observed residues (ATOM records): (download) 
    >2i3cA (A:)
ehiqkvaifggthgneltgvflvkhwlengaeiqrtglevkpfitnpravkkctryidcd
lnrifdlenlgkkmsedlpyevrraqeinhlfgpkdsedsydiifdlhnttsnmgctlil
edsrnnfliqmfhyiktslaplpcyvyliehpslkyattrsiakypvgievgpqpqgvlr
adildqmrkmikhaldfihhfnegkefppcaievykiiekvdyprdengeiaaiihpnlq
dqdwkplhpgdpmfltldgktiplggdctvypvfvneaayyekkeafakttkltlnaksi
rc

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2i3cB (B:)
aiatschiaeehiqkvaifggthgneltgvflvkhwlengaeiqrtglevkpfitnprav
kkctryidcdlnrifdlenlgkkmsedlpyevrraqeinhlfgpkdsedsydiifdlhnt
tsnmgctliledsrnnfliqmfhyiktslaplpcyvyliehpslkyattrsiakypvgie
vgpqpqgvlradildqmrkmikhaldfihhfnegkefppcaievykiiekvdyprdenge
iaaiihpnlqdqdwkplhpgdpmfltldgktiplggdctvypvfvneaayyekkeafakt
tkltlnaksircclh

    Sequence, based on observed residues (ATOM records): (download) 
    >2i3cB (B:)
ehiqkvaifggthgneltgvflvkhwlengaeiqrtglevkpfitnpravkkctryidcd
lnrifdlenlgkkmsedlpyevrraqeinhlfgpkdsedsydiifdlhnttsnmgctlil
edsrnnfliqmfhyiktslaplpcyvyliehpslkyattrsiakypvgievgpqpqgvlr
adildqmrkmikhaldfihhfnegkefppcaievykiiekvdyprdengeiaaiihpnlq
dqdwkplhpgdpmfltldgktiplggdctvypvfvneaayyekkeafakttkltlnaksi
rc