PDB entry 2i0j

View 2i0j on RCSB PDB site
Description: Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia
Class: transcription
Keywords: Nuclear receptor ligand binding domain, TRANSCRIPTION
Deposited on 2006-08-10, released 2006-10-24
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.242
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered (77)
      • engineered (113)
    Domains in SCOPe 2.01: d2i0ja_
  • Chain 'B':
    Compound: Estrogen receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (Start-243)
      • engineered (77)
      • engineered (113)
    Domains in SCOPe 2.01: d2i0jb_
  • Chain 'C':
    Compound: Estrogen receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered (77)
      • engineered (113)
    Domains in SCOPe 2.01: d2i0jc_
  • Chain 'D':
    Compound: Estrogen receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (Start-243)
      • engineered (77)
      • engineered (113)
    Domains in SCOPe 2.01: d2i0jd_
  • Heterogens: I0G

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2i0jA (A:)
    nslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakr
    vpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmve
    ifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkit
    dtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvplydlllem
    ldah
    

    Sequence, based on observed residues (ATOM records): (download)
    >2i0jA (A:)
    lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
    gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
    dmllatssrfrmmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtli
    hlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysm
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2i0jB (B:)
    nslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakr
    vpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmve
    ifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkit
    dtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvplydlllem
    ldah
    

    Sequence, based on observed residues (ATOM records): (download)
    >2i0jB (B:)
    lalsltadqmvsalldaeppilyseydasmmglltnladrelvhminwakrvpgfvdltl
    hdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllats
    srfrmmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtlihlmakag
    ltlqqqhqrlaqlllilshirhmsnkgmehlysmplydlllemldah
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2i0jC (C:)
    nslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakr
    vpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmve
    ifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkit
    dtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvplydlllem
    ldah
    

    Sequence, based on observed residues (ATOM records): (download)
    >2i0jC (C:)
    lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
    gfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveif
    dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
    lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysm
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >2i0jD (D:)
    nslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakr
    vpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmve
    ifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkit
    dtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvplydlllem
    ldah
    

    Sequence, based on observed residues (ATOM records): (download)
    >2i0jD (D:)
    lalsltadqmvsalldaeppilyseydsmmglltnladrelvhminwakrvpgfvdltlh
    dqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllatss
    rfrmmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtlihlmakagl
    tlqqqhqrlaqlllilshirhmsnkgmehlysmlydlllemldah