PDB entry 2hwm
View 2hwm on RCSB PDB site
Description: Crystal structure of Lys12Val/Cys117Val mutant of human acidic fibroblast growth factor at 1.60 angstrom resolution
Class: hormone/growth factor
Keywords: beta-trefoil, HORMONE/GROWTH FACTOR COMPLEX
Deposited on
2006-08-01, released
2007-06-12
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.191
AEROSPACI score: 0.59
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: heparin-binding growth factor 1
Species: Homo sapiens [TaxId:9606]
Gene: FGF1, FGFA
Database cross-references and differences (RAF-indexed):
- Uniprot P05230
- engineered (17)
- engineered (122)
Domains in SCOPe 2.08: d2hwma1, d2hwma2 - Chain 'B':
Compound: heparin-binding growth factor 1
Species: Homo sapiens [TaxId:9606]
Gene: FGF1, FGFA
Database cross-references and differences (RAF-indexed):
- Uniprot P05230
- engineered (17)
- engineered (122)
Domains in SCOPe 2.08: d2hwmb1, d2hwmb2 - Heterogens: FMT, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2hwmA (A:)
hhhhhhfnlppgnykkpvllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgev
yikstetgqylamdtdgllygsqtpneeclflerleenhyntyiskkhaeknwfvglkkn
gsvkrgprthygqkailflplpvssd
Sequence, based on observed residues (ATOM records): (download)
>2hwmA (A:)
hhhhfnlppgnykkpvllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgevyi
kstetgqylamdtdgllygsqtpneeclflerleenhyntyiskkhaeknwfvglkkngs
vkrgprthygqkailflplpv
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2hwmB (B:)
hhhhhhfnlppgnykkpvllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgev
yikstetgqylamdtdgllygsqtpneeclflerleenhyntyiskkhaeknwfvglkkn
gsvkrgprthygqkailflplpvssd
Sequence, based on observed residues (ATOM records): (download)
>2hwmB (B:)
hhhhfnlppgnykkpvllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgevyi
kstetgqylamdtdgllygsqtpneeclflerleenhyntyiskkhaeknwfvglkkngs
vkrgprthygqkailflplpv