PDB entry 2hw7

View 2hw7 on RCSB PDB site
Description: Crystal Structure of Mnk2-D228G in complex with Staurosporine
Class: transferase
Keywords: protein kinases, drug, inhibitor, phosphorylation, TRANSFERASE
Deposited on 2006-08-01, released 2006-08-29
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.71 Å
R-factor: 0.203
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MAP kinase-interacting serine/threonine-protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: MKNK2, MNK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9HBH9 (2-End)
      • cloning artifact (0-1)
      • engineered (158)
    Domains in SCOPe 2.03: d2hw7a_
  • Heterogens: ZN, STU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2hw7A (A:)
gstdsfsgrfedvyqlqedvlgegaharvqtcinlitsqeyavkiiekqpghirsrvfre
vemlyqcqghrnvlelieffeeedrfylvfekmrggsilshihkrrhfneleasvvvqdv
asaldflhnkgiahrdlkpenilcehpnqvspvkicdfglgsgiklngdcspistpellt
pcgsaeymapevveafseeasiydkrcdlwslgvilyillsgyppfvgrcgsdcgwdrge
acpacqnmlfesiqegkyefpdkdwahiscaakdliskllvrdakqrlsaaqvlqhpwvq
gcapentlptpmvlqr

    Sequence, based on observed residues (ATOM records): (download) 
    >2hw7A (A:)
gstdsfsgrfedvyqlqedvlgegaharvqtcinlitsqeyavkiiekqpghirsrvfre
vemlyqcqghrnvlelieffeeedrfylvfekmrggsilshihkrrhfneleasvvvqdv
asaldflhnkgiahrdlkpenilcehpnqvspvkicdfggsaeymapevveafseeasiy
dkrcdlwslgvilyillsgyppfvgrccgacpacqnmlfesiqegkyefpdkdwahisca
akdliskllvrdakqrlsaaqvlqhpwvqgc