PDB entry 2hs1

View 2hs1 on RCSB PDB site
Description: Ultra-high resolution X-ray crystal structure of HIV-1 protease V32I mutant with TMC114 (darunavir) inhibitor
Class: hydrolase
Keywords: ultra-high resolution active site surface binding site, HYDROLASE
Deposited on 2006-07-20, released 2006-10-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 0.84 Å
R-factor: 0.126
AEROSPACI score: 1.22 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: hiv-1 protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: GAG
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03368
    • engineered (6)
    • engineered (31-32)
    • engineered (62)
    • engineered (66)
    • engineered (94)
  Domains in SCOPe 2.07: d2hs1a_
• Chain 'B':
  Compound: hiv-1 protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: GAG
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03368 (0-98)
    • engineered (6)
    • engineered (31-32)
    • engineered (62)
    • engineered (66)
    • engineered (94)
  Domains in SCOPe 2.07: d2hs1b_
• Heterogens: CL, 017, DMS, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2hs1A (A:)
  pqitlwkrplvtikiggqlkealldtgaddtiieemslpgrwkpkmiggiggfikvrqyd
  qiiieiaghkaigtvlvgptpvniigrnlltqigatlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2hs1B (B:)
  pqitlwkrplvtikiggqlkealldtgaddtiieemslpgrwkpkmiggiggfikvrqyd
  qiiieiaghkaigtvlvgptpvniigrnlltqigatlnf