PDB entry 2hre

View 2hre on RCSB PDB site
Description: Structure of human ferrochelatase variant E343K with protoporphyrin IX bound
Class: lyase
Keywords: Heme synthesis, Ferrochelatase, Protoporphyrin IX, LYASE
Deposited on 2006-07-20, released 2007-03-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.216
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ferrochelatase
    Species: Homo sapiens [TaxId:9606]
    Gene: FECH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22830 (0-358)
      • engineered (278)
    Domains in SCOPe 2.07: d2hrea_
  • Chain 'B':
    Compound: Ferrochelatase
    Species: Homo sapiens [TaxId:9606]
    Gene: FECH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22830 (0-358)
      • engineered (278)
    Domains in SCOPe 2.07: d2hreb_
  • Chain 'C':
    Compound: Ferrochelatase
    Species: Homo sapiens [TaxId:9606]
    Gene: FECH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22830 (0-358)
      • engineered (278)
    Domains in SCOPe 2.07: d2hrec_
  • Chain 'D':
    Compound: Ferrochelatase
    Species: Homo sapiens [TaxId:9606]
    Gene: FECH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22830 (0-358)
      • engineered (278)
    Domains in SCOPe 2.07: d2hred_
  • Heterogens: PP9, CHD, FES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2hreA (A:)
rkpktgilmlnmggpetlgdvhdfllrlfldrdlmtlpiqnklapfiakrrtpkiqeqyr
rigggspikiwtskqgegmvklldelspntaphkyyigfryvhplteeaieemerdgler
aiaftqypqyscsttgsslnaiyryynqvgrkptmkwstidrwpthhlliqcfadhilke
ldhfplekrsevvilfsahslpmsvvnrgdpypqevsatvqkvmerleycnpyrlvwqsk
vgpmpwlgpqtdesikglcergrknillvpiaftsdhiktlyeldieysqvlakecgven
irraeslngnplfskaladlvhshiqsnelcskqltlscplcvnpvcretksfftsqql

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2hreB (B:)
rkpktgilmlnmggpetlgdvhdfllrlfldrdlmtlpiqnklapfiakrrtpkiqeqyr
rigggspikiwtskqgegmvklldelspntaphkyyigfryvhplteeaieemerdgler
aiaftqypqyscsttgsslnaiyryynqvgrkptmkwstidrwpthhlliqcfadhilke
ldhfplekrsevvilfsahslpmsvvnrgdpypqevsatvqkvmerleycnpyrlvwqsk
vgpmpwlgpqtdesikglcergrknillvpiaftsdhiktlyeldieysqvlakecgven
irraeslngnplfskaladlvhshiqsnelcskqltlscplcvnpvcretksfftsqql

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2hreC (C:)
rkpktgilmlnmggpetlgdvhdfllrlfldrdlmtlpiqnklapfiakrrtpkiqeqyr
rigggspikiwtskqgegmvklldelspntaphkyyigfryvhplteeaieemerdgler
aiaftqypqyscsttgsslnaiyryynqvgrkptmkwstidrwpthhlliqcfadhilke
ldhfplekrsevvilfsahslpmsvvnrgdpypqevsatvqkvmerleycnpyrlvwqsk
vgpmpwlgpqtdesikglcergrknillvpiaftsdhiktlyeldieysqvlakecgven
irraeslngnplfskaladlvhshiqsnelcskqltlscplcvnpvcretksfftsqql

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2hreD (D:)
rkpktgilmlnmggpetlgdvhdfllrlfldrdlmtlpiqnklapfiakrrtpkiqeqyr
rigggspikiwtskqgegmvklldelspntaphkyyigfryvhplteeaieemerdgler
aiaftqypqyscsttgsslnaiyryynqvgrkptmkwstidrwpthhlliqcfadhilke
ldhfplekrsevvilfsahslpmsvvnrgdpypqevsatvqkvmerleycnpyrlvwqsk
vgpmpwlgpqtdesikglcergrknillvpiaftsdhiktlyeldieysqvlakecgven
irraeslngnplfskaladlvhshiqsnelcskqltlscplcvnpvcretksfftsqql