PDB entry 2hnd

View 2hnd on RCSB PDB site
Description: Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine
Class: Transferase
Keywords: HIV-1 REVERSE TRANSCRIPTASE, AIDS, NON-NUCLEOSIDE INHIBITOR, NEVIRAPINE, DRUG RESISTANCE MUTATIONS, DRUG DESIGN, Transferase
Deposited on 2006-07-12, released 2006-09-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.197
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Reverse transcriptase/ribonuclease H
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (0-533)
      • engineered (97)
      • modified residue (276)
    Domains in SCOPe 2.08: d2hnda1, d2hnda2
  • Chain 'B':
    Compound: Reverse transcriptase/ribonuclease H
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (0-421)
      • engineered (94)
    Domains in SCOPe 2.08: d2hndb_
  • Heterogens: PO4, MG, NVP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2hndA (A:)
pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfai
kkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglekkksvtvldvgdayfsvplded
frkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqy
mddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqp
ivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelel
aenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtn
dvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplv
klwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelqaiy
lalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvp

    Sequence, based on observed residues (ATOM records): (download) 
    >2hndA (A:)
pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfai
kkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglekkksvtvldvgdayfsvplded
frkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqy
mddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqp
ivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelel
aenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtn
dvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplv
klwyqlekepivgaetfyvdagyvtnrgrqkvvtltdttnqktelqaiylalqdsglevn
ivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2hndB (B:)
tvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkk
dstkwrklvdfrelnkrtqdfwevqlgiphpaglekkksvtvldvgdayfsvpldedfrk
ytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymdd
lyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivl
pekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaen
reilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvk
qlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklw
yq

    Sequence, based on observed residues (ATOM records): (download) 
    >2hndB (B:)
tvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkk
dstkwrklvdfrelnkrtqdfwphpaglekkksvtvldvgdayfsvpldedfrkytafti
psinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgsd
leigqhrtkieelrqhllrwppfelhpdkwtvqpivlpekdswtvndiqklvgklnwasq
iypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaei
qkqgqgqwtyqiyqepfknlktgkyartndvkqlteavqkittesiviwgktpkfklpiq
ketwetwwteywqatwipewefvntpplvklwyq