PDB entry 2hle
View 2hle on RCSB PDB site
Description: Structural and biophysical characterization of the EPHB4-EPHRINB2 protein protein interaction and receptor specificity.
Class: transferase/transferase receptor
Keywords: Protein-protein interaction, Receptor tryosine kinase, Bi-directional cell signaling, TRANSFERASE-TRANSFERASE RECEPTOR COMPLEX, Structural Genomics, PSI-2, Protein Structure Initiative, Accelerated Technologies Center for Gene to 3D Structure, ATCG3D
Deposited on
2006-07-06, released
2006-08-22
The last revision prior to the SCOPe 2.02 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.229
AEROSPACI score: 0.36
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Ephrin type-B receptor 4
Species: Homo sapiens [TaxId:9606]
Gene: EPHB4, HTK
Database cross-references and differences (RAF-indexed):
- Uniprot P54760 (8-187)
- cloning artifact (0-1)
- expression tag (2-7)
Domains in SCOPe 2.02: d2hlea1 - Chain 'B':
Compound: ephrin-b2
Species: Homo sapiens [TaxId:9606]
Gene: EFNB2, EPLG5, HTKL, LERK5
Database cross-references and differences (RAF-indexed):
- Uniprot P52799 (0-137)
- conflict (75)
- conflict (80)
Domains in SCOPe 2.02: d2hleb_ - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>2hleA (A:)
aghhhhhheetllntkletadlkwvtfpqvdgqweelsgldeeqhsvrtyevcdvqrapg
qahwlrtgwvprrgavhvyatlrftmleclslpragrscketftvfyyesdadtataltp
awmenpyikvdtvaaehltrkrpgaeatgkvnvktlrlgplskagfylafqdqgacmall
slhlfykk
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2hleB (B:)
ivlepiywnssnskflpgqglvlypqigdkldiicpkvdsktvgqyeyykvymvdkdqad
rctikkentpllncarpdqdvkftikfqefspnlwglefqknkdyyiistsngslegldn
qeggvcqtramkilmkvg
Sequence, based on observed residues (ATOM records): (download)
>2hleB (B:)
ivlepiywnssnskflpgqglvlypqigdkldiicpkvdsktvqyeyykvymvdkdqadr
ctikpllncarpdqdvkftikfqefspnlwglefqknkdyyiistsngslegldnqeggv
cqtramkilmkvg