PDB entry 2hg8

View 2hg8 on RCSB PDB site
Description: Crystal Structure of Cys315Ala mutant of human mitochondrial branched chain aminotransferase complexed with its substrate mimic, N-methyl leucine.
Class: transferase
Keywords: D-aminoacid aminotransferase-like PLP-dependent enzymes, TRANSFERASE
Deposited on 2006-06-26, released 2006-10-24
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.252
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Branched-chain-amino-acid aminotransferase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: BCAT2, BCATM, ECA40
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15382
      • conflict (158)
      • engineered (314)
    Domains in SCOPe 2.01: d2hg8a_
  • Chain 'B':
    Compound: Branched-chain-amino-acid aminotransferase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: BCAT2, BCATM, ECA40
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15382 (Start-364)
      • conflict (158)
      • engineered (314)
    Domains in SCOPe 2.01: d2hg8b_
  • Heterogens: PLP, MLE, ACY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2hg8A (A:)
asssfkaadlqlemtqkphkkpgpgeplvfgktftdhmlmvewndkgwgqpriqpfqnlt
lhpassslhyslqlfegmkafkgkdqqvrlfrpwlnmdrmlrsamrlclpsfdklellec
irrlievdkdwvpdaagtslyvrpvlignepslgvsqprrallfvilcpvgayfpggsvt
pvslladpafirawvggvgnyklggnygptvlvqqealkrgceqvlwlygpdhqltevgt
mnifvywthedgvlelvtpplngvilpgvvrqslldmaqtwgefrvvertitmkqllral
eegrvrevfgsgtaaqvcpvhrilykdrnlhiptmengpelilrfqkelkeiqygirahe
wmfpv

    Sequence, based on observed residues (ATOM records): (download) 
    >2hg8A (A:)
ssfkaadlqlemtqkphkkpgpgeplvfgktftdhmlmvewndkgwgqpriqpfqnltlh
passslhyslqlfegmkafkgkdqqvrlfrpwlnmdrmlrsamrlclpsfdklellecir
rlievdkdwvpdaagtslyvrpvlignepslgvsqprrallfvilcpvgavtpvslladp
afirawvggvgnyklggnygptvlvqqealkrgceqvlwlygpdhqltevgtmnifvywt
hedgvlelvtpplngvilpgvvrqslldmaqtwgefrvvertitmkqllraleegrvrev
fgsgtaaqvcpvhrilykdrnlhiptmengpelilrfqkelkeiqygirahewmfpv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2hg8B (B:)
asssfkaadlqlemtqkphkkpgpgeplvfgktftdhmlmvewndkgwgqpriqpfqnlt
lhpassslhyslqlfegmkafkgkdqqvrlfrpwlnmdrmlrsamrlclpsfdklellec
irrlievdkdwvpdaagtslyvrpvlignepslgvsqprrallfvilcpvgayfpggsvt
pvslladpafirawvggvgnyklggnygptvlvqqealkrgceqvlwlygpdhqltevgt
mnifvywthedgvlelvtpplngvilpgvvrqslldmaqtwgefrvvertitmkqllral
eegrvrevfgsgtaaqvcpvhrilykdrnlhiptmengpelilrfqkelkeiqygirahe
wmfpv

    Sequence, based on observed residues (ATOM records): (download) 
    >2hg8B (B:)
ssfkaadlqlemtqkphkkpgpgeplvfgktftdhmlmvewndkgwgqpriqpfqnltlh
passslhyslqlfegmkafkgkdqqvrlfrpwlnmdrmlrsamrlclpsfdklellecir
rlievdkdwvpdaagtslyvrpvlignepslgvsqprrallfvilcpvgayfpggsvtpv
slladpafirawvggvgnyklggnygptvlvqqealkrgceqvlwlygpdhqltevgtmn
ifvywthedgvlelvtpplngvilpgvvrqslldmaqtwgefrvvertitmkqllralee
grvrevfgsgtaaqvcpvhrilykdrnlhiptmengpelilrfqkelkeiqygirahewm
fpv