PDB entry 2hdx
View 2hdx on RCSB PDB site
Description: Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide
Class: signaling protein
Keywords: SH2, Jak2, phosphotyrosine, adapter protein, SIGNALING PROTEIN
Deposited on
2006-06-21, released
2006-08-08
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-02-24, with a file datestamp of
2009-02-03.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.21
AEROSPACI score: 0.34
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: SH2-B PH domain containing signaling mediator 1 gamma isoform
Species: Mus musculus [TaxId:10090]
Gene: Sh2bpsm1
Database cross-references and differences (RAF-indexed):
- Uniprot Q9WVM5 (Start-110)
- engineered (66-67)
- engineered (76)
Domains in SCOPe 2.08: d2hdxa_ - Chain 'B':
Compound: SH2-B PH domain containing signaling mediator 1 gamma isoform
Species: Mus musculus [TaxId:10090]
Gene: Sh2bpsm1
Database cross-references and differences (RAF-indexed):
- Uniprot Q9WVM5 (Start-110)
- engineered (66-67)
- engineered (76)
Domains in SCOPe 2.08: d2hdxb_ - Chain 'C':
Compound: SH2-B PH domain containing signaling mediator 1 gamma isoform
Species: Mus musculus [TaxId:10090]
Gene: Sh2bpsm1
Database cross-references and differences (RAF-indexed):
- Uniprot Q9WVM5 (Start-110)
- engineered (66-67)
- engineered (76)
Domains in SCOPe 2.08: d2hdxc_ - Chain 'D':
Compound: SH2-B PH domain containing signaling mediator 1 gamma isoform
Species: Mus musculus [TaxId:10090]
Gene: Sh2bpsm1
Database cross-references and differences (RAF-indexed):
- Uniprot Q9WVM5 (Start-110)
- engineered (66-67)
- engineered (76)
Domains in SCOPe 2.08: d2hdxd_ - Chain 'E':
Compound: SH2-B PH domain containing signaling mediator 1 gamma isoform
Species: Mus musculus [TaxId:10090]
Gene: Sh2bpsm1
Database cross-references and differences (RAF-indexed):
- Uniprot Q9WVM5 (Start-110)
- engineered (66-67)
- engineered (76)
Domains in SCOPe 2.08: d2hdxe_ - Chain 'F':
Compound: SH2-B PH domain containing signaling mediator 1 gamma isoform
Species: Mus musculus [TaxId:10090]
Gene: Sh2bpsm1
Database cross-references and differences (RAF-indexed):
- Uniprot Q9WVM5 (Start-110)
- engineered (66-67)
- engineered (76)
Domains in SCOPe 2.08: d2hdxf_ - Chain 'G':
Compound: Jak2 protein
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'H':
Compound: Jak2 protein
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'I':
Compound: Jak2 protein
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'J':
Compound: Jak2 protein
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'K':
Compound: Jak2 protein
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: Jak2 protein
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2hdxA (A:)
gsdqplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakh
lrlslnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps
Sequence, based on observed residues (ATOM records): (download)
>2hdxA (A:)
qplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakhlrl
slnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2hdxB (B:)
gsdqplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakh
lrlslnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps
Sequence, based on observed residues (ATOM records): (download)
>2hdxB (B:)
qplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakhlrl
slnaagqcrvqhlhfqsifdmlehfrvhpiplessdvvlvsyvps
- Chain 'C':
Sequence, based on SEQRES records: (download)
>2hdxC (C:)
gsdqplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakh
lrlslnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps
Sequence, based on observed residues (ATOM records): (download)
>2hdxC (C:)
qplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakhlrl
slnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps
- Chain 'D':
Sequence, based on SEQRES records: (download)
>2hdxD (D:)
gsdqplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakh
lrlslnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps
Sequence, based on observed residues (ATOM records): (download)
>2hdxD (D:)
qplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakhlrl
slnaagqcrvqhlhfqsifdmlehfrvhpiplessdvvlvsyvps
- Chain 'E':
Sequence, based on SEQRES records: (download)
>2hdxE (E:)
gsdqplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakh
lrlslnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps
Sequence, based on observed residues (ATOM records): (download)
>2hdxE (E:)
qplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakhlrl
slnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps
- Chain 'F':
Sequence, based on SEQRES records: (download)
>2hdxF (F:)
gsdqplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakh
lrlslnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps
Sequence, based on observed residues (ATOM records): (download)
>2hdxF (F:)
qplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakhlrl
slnaagqcrvqhlhfqsifdmlehfrvhpiplesdvvlvsyvps
- Chain 'G':
No sequence available.
- Chain 'H':
No sequence available.
- Chain 'I':
No sequence available.
- Chain 'J':
No sequence available.
- Chain 'K':
No sequence available.
- Chain 'L':
No sequence available.