PDB entry 2hdx

View 2hdx on RCSB PDB site
Description: Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide
Class: signaling protein
Keywords: SH2, Jak2, phosphotyrosine, adapter protein, SIGNALING PROTEIN
Deposited on 2006-06-21, released 2006-08-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.21
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: SH2-B PH domain containing signaling mediator 1 gamma isoform
    Species: Mus musculus [TaxId:10090]
    Gene: Sh2bpsm1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WVM5 (Start-110)
      • engineered (66-67)
      • engineered (76)
    Domains in SCOPe 2.08: d2hdxa_
  • Chain 'B':
    Compound: SH2-B PH domain containing signaling mediator 1 gamma isoform
    Species: Mus musculus [TaxId:10090]
    Gene: Sh2bpsm1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WVM5 (Start-110)
      • engineered (66-67)
      • engineered (76)
    Domains in SCOPe 2.08: d2hdxb_
  • Chain 'C':
    Compound: SH2-B PH domain containing signaling mediator 1 gamma isoform
    Species: Mus musculus [TaxId:10090]
    Gene: Sh2bpsm1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WVM5 (Start-110)
      • engineered (66-67)
      • engineered (76)
    Domains in SCOPe 2.08: d2hdxc_
  • Chain 'D':
    Compound: SH2-B PH domain containing signaling mediator 1 gamma isoform
    Species: Mus musculus [TaxId:10090]
    Gene: Sh2bpsm1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WVM5 (Start-110)
      • engineered (66-67)
      • engineered (76)
    Domains in SCOPe 2.08: d2hdxd_
  • Chain 'E':
    Compound: SH2-B PH domain containing signaling mediator 1 gamma isoform
    Species: Mus musculus [TaxId:10090]
    Gene: Sh2bpsm1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WVM5 (Start-110)
      • engineered (66-67)
      • engineered (76)
    Domains in SCOPe 2.08: d2hdxe_
  • Chain 'F':
    Compound: SH2-B PH domain containing signaling mediator 1 gamma isoform
    Species: Mus musculus [TaxId:10090]
    Gene: Sh2bpsm1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WVM5 (Start-110)
      • engineered (66-67)
      • engineered (76)
    Domains in SCOPe 2.08: d2hdxf_
  • Chain 'G':
    Compound: Jak2 protein
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7TQD0 (0-End)
      • modified residue (3)
  • Chain 'H':
    Compound: Jak2 protein
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7TQD0
      • modified residue (3)
  • Chain 'I':
    Compound: Jak2 protein
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7TQD0
      • modified residue (3)
  • Chain 'J':
    Compound: Jak2 protein
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7TQD0
      • modified residue (3)
  • Chain 'K':
    Compound: Jak2 protein
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7TQD0
      • modified residue (3)
  • Chain 'L':
    Compound: Jak2 protein
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7TQD0 (0-End)
      • modified residue (3)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2hdxA (A:)
gsdqplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakh
lrlslnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps

    Sequence, based on observed residues (ATOM records): (download) 
    >2hdxA (A:)
qplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakhlrl
slnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2hdxB (B:)
gsdqplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakh
lrlslnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps

    Sequence, based on observed residues (ATOM records): (download) 
    >2hdxB (B:)
qplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakhlrl
slnaagqcrvqhlhfqsifdmlehfrvhpiplessdvvlvsyvps

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2hdxC (C:)
gsdqplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakh
lrlslnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps

    Sequence, based on observed residues (ATOM records): (download) 
    >2hdxC (C:)
qplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakhlrl
slnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2hdxD (D:)
gsdqplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakh
lrlslnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps

    Sequence, based on observed residues (ATOM records): (download) 
    >2hdxD (D:)
qplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakhlrl
slnaagqcrvqhlhfqsifdmlehfrvhpiplessdvvlvsyvps

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2hdxE (E:)
gsdqplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakh
lrlslnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps

    Sequence, based on observed residues (ATOM records): (download) 
    >2hdxE (E:)
qplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakhlrl
slnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2hdxF (F:)
gsdqplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakh
lrlslnaagqcrvqhlhfqsifdmlehfrvhpiplesggssdvvlvsyvps

    Sequence, based on observed residues (ATOM records): (download) 
    >2hdxF (F:)
qplsgypwfhgmlsrlkaaqlvleggtgshgvflvrqsetrrgecvltfnfqgkakhlrl
slnaagqcrvqhlhfqsifdmlehfrvhpiplesdvvlvsyvps

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    No sequence available.