PDB entry 2hdh

View 2hdh on RCSB PDB site
Description: biochemical characterization and structure determination of human heart short chain l-3-hydroxyacyl coa dehydrogenase provide insight into catalytic mechanism
Class: oxidoreductase
Keywords: oxidoreductase, beta oxidation, schad, catalytic activity: l-3-hydroxyacyl-coa + nad(+) = 3-oxoacyl-coa + nadh
Deposited on 1998-12-04, released 1999-05-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.198
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: l-3-hydroxyacyl coa dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16836 (0-290)
      • conflict (70)
      • conflict (113)
      • conflict (128)
    Domains in SCOPe 2.08: d2hdha1, d2hdha2
  • Chain 'B':
    Compound: l-3-hydroxyacyl coa dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16836 (0-290)
      • conflict (70)
      • conflict (113)
      • conflict (128)
    Domains in SCOPe 2.08: d2hdhb1, d2hdhb2
  • Heterogens: NAD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2hdhA (A:)
kiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgieeslrkvakkkfa
enpkagdefvaktlstiatstdaasvvhstdlvveaivenlkvknelfkrldkraaehti
fasntsslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqktfeslvdfska
lgkhpvsckdtpgfivnrllvpylmeairlyergdaskedidtamklgagypmgpfelld
yvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfykykaa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2hdhB (B:)
kiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgieeslrkvakkkfa
enpkagdefvaktlstiatstdaasvvhstdlvveaivenlkvknelfkrldkraaehti
fasntsslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqktfeslvdfska
lgkhpvsckdtpgfivnrllvpylmeairlyergdaskedidtamklgagypmgpfelld
yvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfykykaa

    Sequence, based on observed residues (ATOM records): (download) 
    >2hdhB (B:)
kiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgieeslrkvakkkfa
enpkagdefvaktlstiatstdaasvvhstdlvveaivenlkvknelfkrldkraaehti
fasntsslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqktfeslvdfska
lgkhpvsckdtpgfivnrllvpylmeairlyergdaskedidtamklgagypmgpfelld
yvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfykyk