PDB entry 2hc1

View 2hc1 on RCSB PDB site
Description: Engineered catalytic domain of protein tyrosine phosphatase HPTPbeta.
Class: Hydrolase
Keywords: protein tyrosine phosphatase, WPD-loop, sulfamic acid, phosphatase, inhibitor, drug design, Hydrolase
Deposited on 2006-06-14, released 2006-06-27
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-06-09, with a file datestamp of 2009-06-05.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: 0.136
AEROSPACI score: 0.78 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor-type tyrosine-protein phosphatase beta
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPRB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23467 (1-285)
      • engineered (73-74)
    Domains in SCOPe 2.03: d2hc1a_
  • Heterogens: ACT, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2hc1A (A:)
snrktscpikinqfeghfmklqadsnyllskeyeelkdvgrnqscdiallpenrgknryn
nilpydatrvklsggsdyinasyipgnnfrreyivtqgplpgtkddfwkmvweqnvhniv
mvtqcvekgrvkcdhywpadqdslyygdlilqmlsesvlpewtirefkicgeeqldahrl
irhfhytvwpdhgvpettqsliqfvrtvrdyinrspgagptvvhcsagvgrtgtfialdr
ilqqldskdsvdiygavhdlrlhrvhmvqtecqyvylhqcvrdvlrarklr

    Sequence, based on observed residues (ATOM records): (download) 
    >2hc1A (A:)
nrktscpikinqfeghfmklqadsnyllskeyeelkdvgrnqscdiallpenrgknrynn
ilpydatrvklsggsdyinasyipgnnfrreyivtqgplpgtkddfwkmvweqnvhnivm
vtqcvekgrvkcdhywpadqdslyygdlilqmlsesvlpewtirefkicgeeqldahrli
rhfhytvwpdhgvpettqsliqfvrtvrdyinrspgagptvvhcsagvgrtgtfialdri
lqqldskdsvdiygavhdlrlhrvhmvqtecqyvylhqcvrdvlrarklr