PDB entry 2hbl

View 2hbl on RCSB PDB site
Description: Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active site and the HRDC domain; Protein in complex with Mn, Zn, and AMP
Class: hydrolase, gene regulation
Keywords: exosome, RNA metabolism, RNA surveillance, RNA processing, HYDROLASE, GENE REGULATION
Deposited on 2006-06-14, released 2006-07-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Exosome complex exonuclease RRP6
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: RRP6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q12149 (2-End)
      • cloning artifact (0-1)
      • engineered (234)
    Domains in SCOPe 2.08: d2hbla1, d2hbla2, d2hbla3
  • Heterogens: ZN, MN, AMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2hblA (A:)
gmvekpqlkfkspidnseshpfipllkekpnalkplseslrlvdddennpshyphpyeye
idhqeyspeilqireeipskswddsvpiwvdtstelesmledlkntkeiavdlehhdyrs
yygivclmqistrerdylvdtlklrenlhilnevftnpsivkvfhgafmdiiwlqrdlgl
yvvglfdtyhaskaiglprhslayllenfanfktskkyqladwrirplskpmtaaaradt
hfllniydqlrnkliesnklagvlyesrnvakrrfeyskyrpltpssevyspiekespwk
ilmyqynipperevlvrelyqwrdliarrddesprfvmpnqllaalvaytptdvigvvsl
tngvtehvrqnakllanlirdalrnikntneeatpipssetkadgillet

    Sequence, based on observed residues (ATOM records): (download) 
    >2hblA (A:)
gmvekpqlkfkspidnseshpfipllkekpnalkplseslrlvdddennpshyphpyeye
idhqeyspeilqireeipskswddsvpiwvdtstelesmledlkntkeiavdlehhdyrs
yygivclmqistrerdylvdtlklrenlhilnevftnpsivkvfhgafmdiiwlqrdlgl
yvvglfdtyhaskaiglprhslayllenfanfktskkyqladwrirplskpmtaaaradt
hfllniydqlrnkliesnklagvlyesrnvakrrfeyskyrpltpssevyspiekespwk
ilmyqynipperevlvrelyqwrdliarrddesprfvmpnqllaalvaytptdvigvvsl
tngvtehvrqnakllanlirdalrnikntn