PDB entry 2h62

View 2h62 on RCSB PDB site
Description: Crystal structure of a ternary ligand-receptor complex of BMP-2
Class: hormone/growth factor
Keywords: TGF-beta superfamily, ligand-receptor complex, HORMONE/GROWTH FACTOR COMPLEX
Deposited on 2006-05-30, released 2007-04-10
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.216
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bone morphogenetic protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BMP2, BMP2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2h62a_
  • Chain 'B':
    Compound: Bone morphogenetic protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BMP2, BMP2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2h62b_
  • Chain 'C':
    Compound: Bone morphogenetic protein receptor type IA
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2h62c_
  • Chain 'D':
    Compound: Acvr2b protein
    Species: Homo sapiens [TaxId:9606]
    Gene: BMPR1A, ACVRLK3, ALK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2h62d_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2h62A (A:)
qakhkqrkrlkssckrhplyvdfsdvgwndwivappgyhafychgecpfpladhlnstnh
aivqtlvnsvnskipkaccvptelsaismlyldenekvvlknyqdmvvegcgcr

    Sequence, based on observed residues (ATOM records): (download) 
    >2h62A (A:)
kssckrhplyvdfsdvgwndwivappgyhafychgecpfpladhlnstnhaivqtlvnsv
nskipkaccvptelsaismlyldenekvvlknyqdmvvegcgcr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2h62B (B:)
qakhkqrkrlkssckrhplyvdfsdvgwndwivappgyhafychgecpfpladhlnstnh
aivqtlvnsvnskipkaccvptelsaismlyldenekvvlknyqdmvvegcgcr

    Sequence, based on observed residues (ATOM records): (download) 
    >2h62B (B:)
ssckrhplyvdfsdvgwndwivappgyhafychgecpfpladhlnstnhaivqtlvnsvn
skipkaccvptelsaismlyldenekvvlknyqdmvvegcgcr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2h62C (C:)
qnldsmlhgtgmksdsdqkksengvtlapedtlpflkcycsghcpddainntcitnghcf
aiieeddqgettlasgcmkyegsdfqckdspkaqlrrtieccrtnlcnqylqptlppvvi
gpffdgsir

    Sequence, based on observed residues (ATOM records): (download) 
    >2h62C (C:)
pflkcycsghcpddainntcitnghcfaiieeddqgettlasgcmkyegsdfqckdspka
qlrrtieccrtnlcnqylqptlpp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2h62D (D:)
sgrgeaetreciyynanwelertnqsglercegeqdkrlhcyaswrnssgtielvkkgcw
lddfncydrqecvateenpqvyfcccegnfcnerfthl

    Sequence, based on observed residues (ATOM records): (download) 
    >2h62D (D:)
aetreciyynanwelertnqsglercegeqdkrlhcyaswrnssgtielvkkgcwlddfn
cydrqecvateenpqvyfcccegnfcnerfthl