PDB entry 2h42

View 2h42 on RCSB PDB site
Description: Crystal structure of PDE5 in complex with sildenafil
Class: hydrolase
Keywords: viagra, PDE5
Deposited on 2006-05-23, released 2006-06-06
The last revision prior to the SCOP 1.73 freeze date was dated 2006-08-08, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.21
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cGMP-specific 3',5'-cyclic phosphodiesterase
    Species: HOMO SAPIENS
    Gene: PDE5A, PDE5
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2h42a1
  • Chain 'B':
    Compound: cGMP-specific 3',5'-cyclic phosphodiesterase
    Species: HOMO SAPIENS
    Gene: PDE5A, PDE5
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2h42b1
  • Chain 'C':
    Compound: cGMP-specific 3',5'-cyclic phosphodiesterase
    Species: HOMO SAPIENS
    Gene: PDE5A, PDE5
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2h42c1
  • Heterogens: ZN, MG, VIA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2h42A (A:)
    eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
    lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
    ldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlk
    iikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpi
    qqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealth
    vsedcfplldgcrknrqkwqalaeqq
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2h42B (B:)
    eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
    lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
    ldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlk
    iikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpi
    qqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealth
    vsedcfplldgcrknrqkwqalaeqq
    

    Sequence, based on observed residues (ATOM records): (download)
    >2h42B (B:)
    eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
    lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
    ldhrgvnnsyiqrchsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailat
    dlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelva
    teffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvsedcfpll
    dgcrknrqkwqalaeqq
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2h42C (C:)
    eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
    lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
    ldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlk
    iikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpi
    qqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealth
    vsedcfplldgcrknrqkwqalaeqq
    

    Sequence, based on observed residues (ATOM records): (download)
    >2h42C (C:)
    eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
    lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
    ldhrgvnnsyiqrchsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailat
    dlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelva
    teffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvsedcfpll
    dgcrknrqkwqalaeqq