PDB entry 2h08

View 2h08 on RCSB PDB site
Description: crystal structure of human phosphoribosyl pyrophosphate synthetase 1 mutant Y146M
Class: transferase
Keywords: PRS1, prpp synthetase 1, phosphoribosyl pyrophosphate synthetase 1, mutant, TRANSFERASE
Deposited on 2006-05-14, released 2006-10-24
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.207
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ribose-phosphate pyrophosphokinase I
    Species: Homo sapiens [TaxId:9606]
    Gene: PRPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60891
      • engineered (145)
    Domains in SCOPe 2.03: d2h08a1, d2h08a2
  • Chain 'B':
    Compound: Ribose-phosphate pyrophosphokinase I
    Species: Homo sapiens [TaxId:9606]
    Gene: PRPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60891
      • engineered (145)
    Domains in SCOPe 2.03: d2h08b1, d2h08b2
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2h08A (A:)
mpnikifsgsshqdlsqkiadrlglelgkvvtkkfsnqetcveigesvrgedvyivqsgc
geindnlmelliminackiasasrvtavipcfpyarqdkkdksrapisaklvanmlsvag
adhiitmdlhasqiqgffdipvdnlmaepavlkwirenisewrnctivspdaggakrvts
iadrlnvdfalihkerkkanevdrmvlvgdvkdrvailvddmadtcgtichaadkllsag
atrvyailthgifsgpaisrinnacfeavvvtntipqedkmkhcskiqvidismilaeai
rrthngesvsylfshvpllehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2h08A (A:)
nikifsgsshqdlsqkiadrlglelgkvvtkkfsnqetcveigesvrgedvyivqsgcge
indnlmelliminackiasasrvtavipcfpyarqdkkdksrapisaklvanmlsvagad
hiitmdlhasqiqgffdipvdnlmaepavlkwirenisewrnctivspdaggakrvtsia
drlnvdfalihkerdrmvlvgdvkdrvailvddmadtcgtichaadkllsagatrvyail
thgifsgpaisrinnacfeavvvtntipqedkmkhcskiqvidismilaeairrthnges
vsylf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2h08B (B:)
mpnikifsgsshqdlsqkiadrlglelgkvvtkkfsnqetcveigesvrgedvyivqsgc
geindnlmelliminackiasasrvtavipcfpyarqdkkdksrapisaklvanmlsvag
adhiitmdlhasqiqgffdipvdnlmaepavlkwirenisewrnctivspdaggakrvts
iadrlnvdfalihkerkkanevdrmvlvgdvkdrvailvddmadtcgtichaadkllsag
atrvyailthgifsgpaisrinnacfeavvvtntipqedkmkhcskiqvidismilaeai
rrthngesvsylfshvpllehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2h08B (B:)
nikifsgsshqdlsqkiadrlglelgkvvtkkfsnqetcveigesvrgedvyivqsgcge
indnlmelliminackiasasrvtavipcfpyarqdkkdksrapisaklvanmlsvagad
hiitmdlhasqiqgffdipvdnlmaepavlkwirenisewrnctivspdaggakrvtsia
drlnvdfalihkedrmvlvgdvkdrvailvddmadtcgtichaadkllsagatrvyailt
hgifsgpaisrinnacfeavvvtntipqedkmkhcskiqvidismilaeairrthngesv
sylfshvp