PDB entry 2gvz

View 2gvz on RCSB PDB site
Description: Crystal Structure of Complex of Gs- with The Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with MANT-ATP and Mn
Class: lyase
Keywords: adenylyl cyclase, mant-ATP, lyase
Deposited on 2006-05-03, released 2006-07-04
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 3.27 Å
R-factor: 0.275
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Adenylate cyclase type 5
    Species: Canis lupus familiaris [TaxId:9615]
    Gene: ADENYLYL CYCLASE TYPE V
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30803
      • engineered (120)
    Domains in SCOPe 2.01: d2gvza1
  • Chain 'B':
    Compound: Adenylate cyclase type 2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: ADENYLYL CYCLASE TYPE II
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2gvzb1
  • Chain 'C':
    Compound: Guanine nucleotide-binding protein G(s), alpha subunit
    Species: Bos taurus [TaxId:9913]
    Gene: GNAS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2gvzc1, d2gvzc2
  • Heterogens: MN, CL, GSP, FKP, ONA

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2gvzA (A:)
mhhhhhhamemkadinakqedmmfhkiyiqkhdnvsilfadiegftslasqctaqelvmt
lnelfarfdklaaenhclrikilgdcyycvsglpearadhahccvemgmdmieaislvre
mtgvnvnmrvgihsgrvhcgvlglrkwqfdvwsndvtlanhmeaggkagrihitkatlsy
lngdyevepgcggernaylkehsietflilrctqkrkeekamiak

    Sequence, based on observed residues (ATOM records): (download) 
    >2gvzA (A:)
mmfhkiyiqkhdnvsilfadiegftslasqctaqelvmtlnelfarfdklaaenhclrik
ilgdcyycvsglpearadhahccvemgmdmieaislvremtgvnvnmrvgihsgrvhcgv
lglrkwqfdvwsndvtlanhmeaggkagrihitkatlsylngdyevepgcggernaylke
hsietflil

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2gvzB (B:)
rslkneelyhqsydcvcvmfasipdfkefytesdvnkegleclrllneiiadfddllskp
kfsgvekiktigstymaatglsaipsqehaqeperqymhigtmvefayalvgkldainkh
sfndfklrvginhgpviagvigaqkpqydiwgntvnvasrmdstgvldkiqvteetslil
qtlgytctcrgiinvkgkgdlktyfvntemsr

    Sequence, based on observed residues (ATOM records): (download) 
    >2gvzB (B:)
qsydcvcvmfasipdfkefytesdvnkegleclrllneiiadfddllskpkfsgvekikt
igstymaatglsairqymhigtmvefayalvgkldainkhsfndfklrvginhgpviagv
igaqkpqydiwgntvnvasrmdstgvldkiqvteetslilqtlgytctcrgiinvkgkgd
lktyfvnt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2gvzC (C:)
mgclgnsktedqrneekaqreankkiekqlqkdkqvyrathrllllgagesgkstivkqm
rilhvngfngeggeedpqaarsnsdgekatkvqdiknnlkeaietivaamsnlvppvela
npenqfrvdyilsvmnvpdfdfppefyehakalwedegvracyersneyqlidcaqyfld
kidvikqddyvpsdqdllrcrvltsgifetkfqvdkvnfhmfdvggqrderrkwiqcfnd
vtaiifvvasssynmvirednqtnrlqealnlfksiwnnrwlrtisvilflnkqdllaek
vlagkskiedyfpefaryttpedatpepgedprvtrakyfirdeflristasgdgrhycy
phftcavdtenirrvfndcrdiiqrmhlrqyell

    Sequence, based on observed residues (ATOM records): (download) 
    >2gvzC (C:)
athrllllgagesgkstivkqmrilhvgekatkvqdiknnlkeaietivaamsnlvppve
lanpenqfrvdyilsvmnvpdfdfppefyehakalwedegvracyersneyqlidcaqyf
ldkidvikqddyvpsdqdllrcrvltsgifetkfqvdkvnfhmfdvggqrderrkwiqcf
ndvtaiifvvasssynmvirednqtnrlqealnlfksiwnnrwlrtisvilflnkqdlla
ekvlagkskiedyfpefaryttpedatpepgedprvtrakyfirdeflristasgdgrhy
cyphftcavdtenirrvfndcrdiiqrmhl