PDB entry 2gu8
View 2gu8 on RCSB PDB site
Description: Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies
Class: signaling protein,transferase/inhibitor
Keywords: CAMP-dependent protein kinase, PKA, Akt, Kinase, Drug Design, ternary complex, SIGNALING PROTEIN,TRANSFERASE/INHIBITOR COMPLEX
Deposited on
2006-04-28, released
2007-05-01
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.206
AEROSPACI score: 0.37
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: cAMP-dependent protein kinase, alpha-catalytic subunit
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2gu8a_ - Chain 'C':
Compound: inhibitor of CAMP-dependent protein kinase
Database cross-references and differences (RAF-indexed):
- Heterogens: 796, HOH