PDB entry 2gs3

View 2gs3 on RCSB PDB site
Description: Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4)
Class: oxidoreductase
Keywords: GPX4, GSHPX-4,phospholipid hydroperoxide, Structural Genomics, Structural Genomics Consortium, SGC, OXIDOREDUCTASE
Deposited on 2006-04-25, released 2006-05-09
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.173
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phospholipid hydroperoxide glutathione peroxidase
    Species: Homo sapiens [TaxId:9606]
    Gene: GPX4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36969 (23-184)
      • cloning artifact (14-22)
      • engineered (60)
    Domains in SCOPe 2.06: d2gs3a1, d2gs3a2
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2gs3A (A:)
mhhhhhhssgvdlgtenlyfqsmrcarsmhefsakdidghmvnldkyrgfvcivtnvasq
ggktevnytqlvdlharyaecglrilafpcnqfgkqepgsneeikefaagynvkfdmfsk
icvngddahplwkwmkiqpkgkgilgnaikwnftkflidkngcvvkrygpmeeplviekd
lphyf

    Sequence, based on observed residues (ATOM records): (download) 
    >2gs3A (A:)
tenlyfqsmrcarsmhefsakdidghmvnldkyrgfvcivtnvasqggktevnytqlvdl
haryaecglrilafpcnqfgkqepgsneeikefaagynvkfdmfskicvngddahplwkw
mkiqpkgkgilgnaikwnftkflidkngcvvkrygpmeeplviekdlphyf