PDB entry 2gqg
View 2gqg on RCSB PDB site
Description: X-ray Crystal Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain
Class: transferase
Keywords: Kinase, TRANSFERASE
Deposited on
2006-04-20, released
2006-11-21
The last revision prior to the SCOPe 2.05 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-25.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.208
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proto-oncogene tyrosine-protein kinase ABL1
Species: Homo sapiens [TaxId:9606]
Gene: ABL1, ABL, JTK7
Database cross-references and differences (RAF-indexed):
- Uniprot P00519 (6-277)
- cloning artifact (0-5)
- modified residue (170)
Domains in SCOPe 2.05: d2gqga_ - Chain 'B':
Compound: Proto-oncogene tyrosine-protein kinase ABL1
Species: Homo sapiens [TaxId:9606]
Gene: ABL1, ABL, JTK7
Database cross-references and differences (RAF-indexed):
- Uniprot P00519 (6-End)
- cloning artifact (0-5)
- modified residue (170)
Domains in SCOPe 2.05: d2gqgb_ - Heterogens: 1N1, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>2gqgA (A:)
gamdpsspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmevee
flkeaavmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvlly
matqissameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfp
ikwtapeslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpe
gcpekvyelmracwqwnpsdrpsfaeihqafetmfqes
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2gqgB (B:)
gamdpsspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmevee
flkeaavmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvlly
matqissameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfp
ikwtapeslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpe
gcpekvyelmracwqwnpsdrpsfaeihqafetmfqes
Sequence, based on observed residues (ATOM records): (download)
>2gqgB (B:)
gamdpsspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmevee
flkeaavmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvlly
matqissameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfp
ikwtapeslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpe
gcpekvyelmracwqwnpsdrpsfaeihqafetmfqe