PDB entry 2gnl

View 2gnl on RCSB PDB site
Description: PKA threefold mutant model of Rho-kinase with inhibitor H-1152P
Class: transferase/transferase inhibitor
Keywords: PKA, Mutant, Rho-kinase, Surrogate, inhibitor, H-1152P, TRANSFERASE/TRANSFERASE INHIBITOR COMPLEX
Deposited on 2006-04-10, released 2006-05-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.203
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase, alpha-catalytic subunit
    Species: Bos taurus [TaxId:9913]
    Gene: PRKACA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00517 (Start-349)
      • engineered (48)
      • engineered (180)
      • engineered (182)
      • modified residue (196)
      • modified residue (337)
    Domains in SCOPe 2.08: d2gnla_
  • Chain 'I':
    Compound: cAMP-dependent protein kinase inhibitor alpha
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: H52, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2gnlA (A:)
gnaaaakkgseqesvkeflakakedflkkwenpaqntahldqferiktigtgsfgrvmlv
khmetgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvm
eyvpggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyi
kvadfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffa
dqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfatt
dwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

    Sequence, based on observed residues (ATOM records): (download) 
    >2gnlA (A:)
eqesvkeflakakedflkkwenpaqntahldqferiktigtgsfgrvmlvkhmetgnhya
mkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvpggemfs
hlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyikvadfgfakr
vkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyeki
vsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkv
eapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

  • Chain 'I':
    No sequence available.